{"id":"W2551536162","doi":"10.1182/blood.v104.11.2960.2960","title":"Transplantation of Immunodeficient Mice with Chronic Myeloid Leukemia (CML) Cells from Chronic Phase Patients Reveals a Hierarchy of CD34+ Aldehyde Dehydrogenase-Positive Cells with Short- and Long-Term Repopulating Activity and Transient Responsiveness to Imatinib Mesylate in Vivo.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Nod; Biology; Haematopoiesis; CD34; Bone marrow; CD38; Immunology; Transplantation; Severe combined immunodeficiency; Myeloid; Stem cell; Leukemia; Immunophenotyping; Cancer research; Medicine; Antigen; Internal medicine; Cell biology; Endocrinology; In vivo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001968428,0.000347851,0.0002064557,0.0004341208,0.0002011815,0.0002510573,0.0001369444,0.0002868694,0.002529624],"category_scores_gemma":[0.00007113306,0.0001577339,0.0001985913,0.0001917475,0.0001741372,0.0001863855,0.000273458,0.0007394736,0.0004720008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118903,"about_ca_system_score_gemma":0.0001035346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002369098,"about_ca_topic_score_gemma":0.0005311265,"domain_scores_codex":[0.9998591,0.00001727923,0.00001672161,0.00003654394,0.00003099339,0.00003940181],"domain_scores_gemma":[0.9998716,0.0000204931,0.00003200075,0.00001778654,0.00000757449,0.00005049302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001207609,0.00005784897,0.0006062579,0.00001087833,0.000003065234,0.00004412412,0.00001646345,0.00001441332,0.9982139,0.00005270098,0.0000311451,0.0008283872],"study_design_scores_gemma":[0.0001310998,0.00291031,0.0488745,0.00001960221,0.00004669338,0.003647682,0.00008477153,0.001006919,0.9386434,0.0001099263,0.004515506,0.00000958804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965323,0.0006046423,0.001245608,0.00004919661,0.00001151244,0.00005915067,0.0005667787,0.00006990535,0.0008608745],"genre_scores_gemma":[0.9940003,0.000348771,0.001802777,0.00006716472,0.00001061669,0.0001073134,0.001529996,0.00002123927,0.002111759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002529624,"threshold_uncertainty_score":0.008462429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008369133972260287,"score_gpt":0.2499668929042245,"score_spread":0.2415977589319642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}