{"id":"W2551632627","doi":"10.3389/fcimb.2016.00152","title":"An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy","year":2016,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Medical Research Council; Umeå Centre for Microbial Research; Umeå Universitet; Västerbotten Läns Landsting","keywords":"Francisella tularensis; In vitro; Nitric oxide; Microbiology; Tularemia; Biology; Immunology; Virology; Virulence; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003519476,0.0009904801,0.000645289,0.0007305197,0.0002107998,0.0004230108,0.0004714651,0.0008985308,0.001160344],"category_scores_gemma":[0.0002076404,0.0002367506,0.0003523729,0.0001961101,0.000392455,0.0004167709,0.0002547061,0.001618979,0.0004394312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004111013,"about_ca_system_score_gemma":0.0002944721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001282976,"about_ca_topic_score_gemma":0.001988938,"domain_scores_codex":[0.9995406,0.00009057098,0.0000445824,0.00009954347,0.000109139,0.0001156925],"domain_scores_gemma":[0.9996173,0.00009126606,0.0001115065,0.00004825394,0.00004081464,0.00009074403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003403099,0.0001214693,0.0002206572,0.0000298031,0.000004913693,0.00004732139,0.00002120457,0.0001298522,0.9982863,0.00006884703,0.00003527524,0.0006940087],"study_design_scores_gemma":[0.00003051445,0.002013738,0.001506965,0.00001321212,0.00002151231,0.0001829459,0.00003107193,0.001406078,0.994212,0.00004870461,0.000525071,0.000008287307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921793,0.00133855,0.004348973,0.000146289,0.00006363537,0.000064162,0.0004697477,0.0001359481,0.00125344],"genre_scores_gemma":[0.99176,0.0008283789,0.003891976,0.00007919729,0.0000290439,0.0001187481,0.0005382001,0.00002660309,0.002727812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001282976,"threshold_uncertainty_score":0.003881752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004091474375849903,"score_gpt":0.2206244834202563,"score_spread":0.2165330090444064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}