{"id":"W2551682012","doi":"10.1038/srep37721","title":"GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Lee Kong Chian School of Medicine, Nanyang Technological University; Ministry of Education, India; Nanyang Technological University","keywords":"Gene silencing; Biology; Transfection; Jurkat cells; Cell biology; Internalization; Gene; Molecular biology; Cell; Genetics; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487631,0.0002726795,0.0003395372,0.0001269384,0.0001134238,0.0003209803,0.000134276,0.0002199962,0.0009793815],"category_scores_gemma":[0.0001020626,0.0001164325,0.0002801463,0.0001121595,0.0001476291,0.00008475849,0.0002132697,0.000478986,0.0004383493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002926881,"about_ca_system_score_gemma":0.0001724125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005341214,"about_ca_topic_score_gemma":0.0006604462,"domain_scores_codex":[0.999821,0.00002888612,0.0000154293,0.00004726798,0.00003485804,0.00005266395],"domain_scores_gemma":[0.9999248,0.00002226431,0.00001269996,0.00001571056,0.000009827717,0.0000147134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005317627,0.00001218017,0.00005272799,0.00001501486,0.000003261566,0.00002140205,0.00001303921,0.00002998468,0.9993591,0.00003283796,0.00002177776,0.000385639],"study_design_scores_gemma":[0.0000114416,0.0001637634,0.00106063,0.000001848032,0.00001047979,0.00007595772,0.000009897722,0.0004915097,0.9974597,0.00001201966,0.0007016592,0.000001118501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917494,0.001050412,0.005272578,0.00007182608,0.0000268954,0.00005701767,0.0002933035,0.0001230181,0.001355731],"genre_scores_gemma":[0.9952794,0.0004366759,0.002001333,0.00006605073,0.000009626702,0.00005637466,0.0005015889,0.00002198784,0.001626864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009793815,"threshold_uncertainty_score":0.003276408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02243245515044438,"score_gpt":0.2443337333836322,"score_spread":0.2219012782331878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}