{"id":"W2551682012","doi":"10.1038/srep37721","title":"GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Lee Kong Chian School of Medicine, Nanyang Technological University; Ministry of Education, India; Nanyang Technological University","keywords":"Gene silencing; Biology; Transfection; Jurkat cells; Cell biology; Internalization; Gene; Molecular biology; Cell; Genetics; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008506412,0.0001976174,0.0002682659,0.0003167625,0.000263472,0.00009810107,0.0002471724,0.0001842873,0.00146684],"category_scores_gemma":[0.00003675893,0.0001444982,0.00009200681,0.000256792,0.0004583581,0.0002472786,0.0001310281,0.0001527331,0.0003213883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002501211,"about_ca_system_score_gemma":0.00008722182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001030254,"about_ca_topic_score_gemma":0.00000916491,"domain_scores_codex":[0.9977896,0.000229412,0.0007010056,0.0007355744,0.0001052483,0.0004391385],"domain_scores_gemma":[0.9988874,0.00004506116,0.0003112343,0.0006274784,0.0001000988,0.00002869305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003457034,0.00007932912,0.0009245252,0.000008231654,0.00002390897,0.00009469107,0.0003927197,5.511427e-7,0.9774626,0.00003556646,0.0191617,0.001781582],"study_design_scores_gemma":[0.0003019081,0.00004901868,0.0004165038,0.0001300556,0.000006549644,0.0001218654,0.0000622388,2.494816e-7,0.9394745,0.0001811713,0.05906002,0.0001959505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874082,0.002617027,0.0007029173,0.00005775677,0.008183224,0.0002070192,0.000008644568,0.00005942129,0.0007558442],"genre_scores_gemma":[0.9731079,0.00008755835,0.00002749318,0.00004657912,0.00002207856,0.00001849835,0.0001280963,0.00001982898,0.02654202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03989832,"threshold_uncertainty_score":0.999446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02243245515044438,"score_gpt":0.2443337333836322,"score_spread":0.2219012782331878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}