{"id":"W2551906031","doi":"10.1038/srep36928","title":"Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Vetenskapsrådet; Arthritis Society; Cleveland Clinic","keywords":"Inflammation; Hyaluronic acid; Cell biology; Chemistry; Tumor necrosis factor alpha; Hyaluronan synthase; Macrophage; Immunology; Chemokine; Immune system; Extracellular matrix; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500427,0.0002881237,0.0002143297,0.0001250304,0.00006650253,0.0002435905,0.00009383176,0.0002626184,0.001339889],"category_scores_gemma":[0.0001582724,0.0001071724,0.0002317041,0.0001251901,0.0002080596,0.0001507624,0.0001498171,0.0004930661,0.0004428639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001058768,"about_ca_system_score_gemma":0.0001441864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001305549,"about_ca_topic_score_gemma":0.0002196627,"domain_scores_codex":[0.9997808,0.00004573463,0.00002802886,0.00002896955,0.00006670679,0.00004971166],"domain_scores_gemma":[0.9998177,0.00004476734,0.00004165165,0.00003067427,0.00002220803,0.00004313683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001881853,0.00004482185,0.0001612346,0.00004472642,0.000004714517,0.00003883305,0.00001214904,0.00002818042,0.9986713,0.00003312071,0.00001808102,0.0007546569],"study_design_scores_gemma":[0.00005227737,0.001078606,0.006393361,0.00001280112,0.00002251005,0.0003430023,0.0000532457,0.0003406693,0.9887172,0.00007873986,0.002903593,0.000003957452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940847,0.002167082,0.001851688,0.00007524653,0.00005020556,0.00003892185,0.0003240648,0.00002574983,0.001382303],"genre_scores_gemma":[0.9924784,0.001161241,0.001512961,0.0001301222,0.0000236349,0.00006496788,0.0008759375,0.00001174669,0.003740988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339889,"threshold_uncertainty_score":0.004482329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645682859760672,"score_gpt":0.2821985470510096,"score_spread":0.2657417184534028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}