{"id":"W2552051894","doi":"10.1182/blood.v114.22.890.890","title":"First-Line Rituximab Efficacy and Safety in Patients with Acquired Idiopathic Thrombotic Thrombocytopenic Purpura Experiencing a Non Optimal Response to Therapeutical Plasma Exchange: Results of a Prospective Multicenter Phase 2 Study From the French Reference Center for the Management of Thrombotic Microangiopathies.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Rituximab; Medicine; Thrombotic thrombocytopenic purpura; Internal medicine; ADAMTS13; Gastroenterology; Thrombotic microangiopathy; Prospective cohort study; Refractory (planetary science); Surgery; Platelet; Disease; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002048278,0.0009612197,0.001229983,0.0002655757,0.0002674163,0.000488595,0.0004056163,0.0008164101,0.0008205214],"category_scores_gemma":[0.001734051,0.000292735,0.0007844084,0.000211612,0.0005252435,0.0004272845,0.0001856935,0.0009155178,0.0002148601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004751665,"about_ca_system_score_gemma":0.0004525451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003265211,"about_ca_topic_score_gemma":0.0004012985,"domain_scores_codex":[0.9991671,0.0005029369,0.00004515829,0.0001195952,0.00007568435,0.00008959063],"domain_scores_gemma":[0.9988329,0.0003624133,0.0003065316,0.0001196553,0.00006178681,0.0003167492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6237412,0.0542047,0.1500838,0.0004955208,0.003053603,0.001139478,0.000545021,0.001973112,0.03881039,0.0001345998,0.001246789,0.1245719],"study_design_scores_gemma":[0.1862476,0.5992845,0.2052234,0.0000330096,0.0011099,0.001695458,0.00008531654,0.00179676,0.00324825,0.00008363087,0.001154017,0.00003814235],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991164,0.0005298327,0.00008773251,0.00002744026,0.00000659701,0.00006720522,0.00004011381,0.000007283098,0.0001175038],"genre_scores_gemma":[0.998866,0.0002263993,0.0002475543,0.0001165995,0.00005676713,0.000118408,0.0002562504,0.000002518681,0.0001095853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002048278,"threshold_uncertainty_score":0.01083249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02040260314381941,"score_gpt":0.2828149266710213,"score_spread":0.2624123235272019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}