{"id":"W2552051894","doi":"10.1182/blood.v114.22.890.890","title":"First-Line Rituximab Efficacy and Safety in Patients with Acquired Idiopathic Thrombotic Thrombocytopenic Purpura Experiencing a Non Optimal Response to Therapeutical Plasma Exchange: Results of a Prospective Multicenter Phase 2 Study From the French Reference Center for the Management of Thrombotic Microangiopathies.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Rituximab; Medicine; Thrombotic thrombocytopenic purpura; Internal medicine; ADAMTS13; Gastroenterology; Thrombotic microangiopathy; Prospective cohort study; Refractory (planetary science); Surgery; Platelet; Disease; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007736377,0.0003271734,0.0006661077,0.00008902448,0.0002326927,0.0000282504,0.0005273644,0.00008527067,0.0000279995],"category_scores_gemma":[0.00009911422,0.0001936697,0.00007696888,0.0002544588,0.0002278019,0.00009811457,0.0002580378,0.0001452171,0.000004611058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006509615,"about_ca_system_score_gemma":0.00003804465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001316352,"about_ca_topic_score_gemma":0.000175872,"domain_scores_codex":[0.9975165,0.0004518314,0.000825888,0.0006182729,0.000167279,0.0004202661],"domain_scores_gemma":[0.9980417,0.0007016812,0.0003140107,0.0007523353,0.0001562366,0.00003399452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4433341,0.1288536,0.1642652,0.0006047926,0.007845762,0.00006927378,0.18371,0.000340097,0.05965957,0.00009402475,0.0001574259,0.01106606],"study_design_scores_gemma":[0.1077122,0.009454768,0.8718852,0.0008666696,0.0006293659,0.000002951085,0.0041195,0.00004145186,0.005034211,0.000008195141,0.00002658771,0.0002189613],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909133,0.0009605,0.0001719037,0.0002561524,0.00009108438,0.007058463,0.0005176535,0.00002092393,0.000009990559],"genre_scores_gemma":[0.9992136,0.00002775219,0.0002769236,0.00005201587,0.00001392026,0.0003246147,0.00005997069,0.000020724,0.00001052624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.70762,"threshold_uncertainty_score":0.789762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02040260314381941,"score_gpt":0.2828149266710213,"score_spread":0.2624123235272019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}