{"id":"W2552099557","doi":"10.1056/nejmoa1607303","title":"Palbociclib and Letrozole in Advanced Breast Cancer","year":2016,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2948,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Palbociclib; Letrozole; Medicine; Breast cancer; Oncology; Estrogen receptor; Internal medicine; Cancer; Gynecology; Metastatic breast cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199891,0.0003835005,0.001067089,0.0004152374,0.0001367708,0.0003252085,0.0003479334,0.0005005625,0.002681037],"category_scores_gemma":[0.001192057,0.000166054,0.0004891085,0.0003433391,0.0003732562,0.0002394527,0.0002360678,0.001043402,0.0002995909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004625659,"about_ca_system_score_gemma":0.0006939162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004691325,"about_ca_topic_score_gemma":0.0009839531,"domain_scores_codex":[0.9995549,0.0002474073,0.00002611013,0.00005014457,0.00008863845,0.00003280665],"domain_scores_gemma":[0.9995833,0.0001867398,0.00009651155,0.00001734143,0.00002287422,0.00009322952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4718374,0.008765409,0.01198968,0.002934414,0.001833119,0.0003069819,0.0001221852,0.002698619,0.02944209,0.0006270912,0.002826896,0.466616],"study_design_scores_gemma":[0.5737056,0.3372,0.05433339,0.0004318273,0.002236654,0.001073861,0.00006106713,0.002621463,0.009772726,0.00107482,0.01744935,0.00003910567],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491668,0.04402475,0.0007974302,0.001080472,0.0002139465,0.0008612997,0.0003494975,0.00006733199,0.003438518],"genre_scores_gemma":[0.9862699,0.0102078,0.0009618148,0.0005360141,0.0002006881,0.0004237011,0.0003146404,0.000005750411,0.001079703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002681037,"threshold_uncertainty_score":0.008969009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120009148616708,"score_gpt":0.2938672739258823,"score_spread":0.2826671824397152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}