{"id":"W2552176673","doi":"10.1182/blood.v120.21.4055.4055","title":"A Phase 2, Multicenter, Nonrandomized, Open-Label Study of Dovitinib (TKI258) in Patients with Relapsed or Refractory Multiple Myeloma with or without t(4;14) Translocation","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Multiple myeloma; Refractory (planetary science); Internal medicine; Clinical endpoint; Chromosomal translocation; Phases of clinical research; Gastroenterology; Tyrosine-kinase inhibitor; Regimen; Oncology; Clinical trial; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002132488,0.002149151,0.002269099,0.0004414323,0.0005852512,0.0009505489,0.0009054108,0.001513805,0.003333727],"category_scores_gemma":[0.001079253,0.0009113077,0.001118896,0.0004068561,0.001107469,0.001130931,0.0004447853,0.002679902,0.0008275168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008702335,"about_ca_system_score_gemma":0.001566672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007056066,"about_ca_topic_score_gemma":0.001803899,"domain_scores_codex":[0.9994802,0.0002582588,0.00002607603,0.00009569949,0.00004033276,0.00009943442],"domain_scores_gemma":[0.9992608,0.0001335387,0.000153945,0.0000697619,0.00005132213,0.0003306559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8498021,0.07894959,0.01050075,0.0003939384,0.0007309284,0.0002151462,0.000223744,0.001212731,0.03084404,0.0001552615,0.001529536,0.02544223],"study_design_scores_gemma":[0.6071396,0.378799,0.01018059,0.00001308069,0.0002495573,0.0001539309,0.00005010241,0.0007299236,0.001589642,0.0000883751,0.000985526,0.00002076924],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996125,0.0004412029,0.0002275814,0.0001836298,0.00006996372,0.001983449,0.000452481,0.00003873914,0.0004779721],"genre_scores_gemma":[0.9920288,0.000570274,0.001066298,0.0005205339,0.0002155222,0.003028505,0.001223338,0.00001779875,0.001329106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003333727,"threshold_uncertainty_score":0.01127779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05020356072462877,"score_gpt":0.3489929799330997,"score_spread":0.2987894192084709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}