{"id":"W2552391442","doi":"10.1002/pro.3086","title":"New insights into interactions between the nucleotide‐binding domain of CFTR and keratin 8","year":2016,"lang":"en","type":"article","venue":"Protein Science","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Cystic Fibrosis Canada; Narodowe Centrum Nauki; Agence Nationale de la Recherche; Narodowym Centrum Nauki; American Breast Cancer Foundation","keywords":"ΔF508; Cystic fibrosis transmembrane conductance regulator; Chemistry; Binding site; Cyclic nucleotide-binding domain; Plasma protein binding; Mutation; Surface plasmon resonance; Peptide sequence; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004489521,0.00006384568,0.00006681592,0.00004679664,0.0002109662,0.00002546431,0.0003357316,0.00003816186,0.00002283798],"category_scores_gemma":[0.0002282169,0.00003319493,0.00002297898,0.000168974,0.0007185327,0.000009821369,0.0002592883,0.00005706006,0.00001038525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001060685,"about_ca_system_score_gemma":0.0001443848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003069468,"about_ca_topic_score_gemma":0.00002144007,"domain_scores_codex":[0.9992653,0.0000610343,0.0001166143,0.0002525705,0.0001390976,0.0001654507],"domain_scores_gemma":[0.9995349,0.00003013874,0.00004971381,0.0002457128,0.00006005234,0.00007950066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008566428,0.000004243719,0.004472274,0.000002318964,0.000005313786,5.142257e-7,0.000094875,4.354261e-8,0.9746422,0.0004954488,0.0000587532,0.02021542],"study_design_scores_gemma":[0.0001573477,0.0001039172,0.003296475,0.00002344241,0.000001798479,0.000005237258,0.00006696703,0.000002158012,0.9877825,0.001616073,0.006885833,0.00005826275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991472,0.0002375466,0.006566634,0.0007990401,0.00003669509,0.0001954193,0.000001323127,0.000003487862,0.0006878394],"genre_scores_gemma":[0.9965038,0.00002759296,0.002503769,0.00001623555,0.0000910384,0.0000128385,0.000001366248,0.000004089081,0.0008392473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02015715,"threshold_uncertainty_score":0.2647463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576701774871688,"score_gpt":0.2948391100928329,"score_spread":0.279072092344116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}