{"id":"W2552391442","doi":"10.1002/pro.3086","title":"New insights into interactions between the nucleotide‐binding domain of CFTR and keratin 8","year":2016,"lang":"en","type":"article","venue":"Protein Science","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Cystic Fibrosis Canada; Narodowe Centrum Nauki; Agence Nationale de la Recherche; Narodowym Centrum Nauki; American Breast Cancer Foundation","keywords":"ΔF508; Cystic fibrosis transmembrane conductance regulator; Chemistry; Binding site; Cyclic nucleotide-binding domain; Plasma protein binding; Mutation; Surface plasmon resonance; Peptide sequence; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107546,0.0002414979,0.0002043192,0.0001615175,0.0001172895,0.0001686516,0.0002211811,0.0002876573,0.0008308027],"category_scores_gemma":[0.0000874864,0.0001465819,0.0001883984,0.00009494286,0.0001639452,0.0004527101,0.0001886981,0.0003269379,0.0001405611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001590156,"about_ca_system_score_gemma":0.00008031545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004782223,"about_ca_topic_score_gemma":0.0008642895,"domain_scores_codex":[0.9999568,0.000005543631,0.000002307067,0.000008668338,0.00001541601,0.00001125901],"domain_scores_gemma":[0.9999706,0.000009691375,0.000007673223,0.000001876484,0.000004078149,0.00000614191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001202748,0.00003227616,0.00125976,0.0001725158,0.000019586,0.0004663341,0.0001087861,0.0004324718,0.9913943,0.0006234043,0.0001303177,0.005239776],"study_design_scores_gemma":[0.00005780946,0.0006530887,0.04853177,0.0001069552,0.0001511904,0.004170586,0.001213228,0.02527064,0.8858216,0.003782072,0.03018645,0.00005468301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818267,0.01003542,0.005372003,0.0004369443,0.00004176596,0.000009294464,0.0001092133,0.00003977324,0.002128949],"genre_scores_gemma":[0.9889713,0.005142243,0.00445168,0.000177759,0.00002006471,0.000006345167,0.0001358029,0.000009910723,0.00108491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008308027,"threshold_uncertainty_score":0.002779305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576701774871688,"score_gpt":0.2948391100928329,"score_spread":0.279072092344116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}