{"id":"W2552533929","doi":"10.1182/blood.v126.23.3792.3792","title":"Preliminary Report of the Phase 1 Study of the DOT1L Inhibitor, Pinometostat, EPZ-5676, in Children with Relapsed or Refractory MLL-r Acute Leukemia: Safety, Exposure and Target Inhibition","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Leukemia; Cancer research; Medicine; Acute leukemia; Histone H3; Pharmacology; Internal medicine; Biology; Methylation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001141177,0.001056094,0.001273199,0.0002148658,0.0002890531,0.0006573851,0.0006804632,0.0008888033,0.002923179],"category_scores_gemma":[0.0007023555,0.0003726232,0.0009240928,0.0002221669,0.0005001053,0.0005230471,0.0002411937,0.002435528,0.0008487364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005744986,"about_ca_system_score_gemma":0.001159008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008008566,"about_ca_topic_score_gemma":0.002294904,"domain_scores_codex":[0.9995719,0.0001944277,0.00003214474,0.00007164439,0.00006003058,0.00006980525],"domain_scores_gemma":[0.9994697,0.0001294313,0.0001107283,0.00005277715,0.00004374486,0.0001937365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2150909,0.03978655,0.01858466,0.002419894,0.002262469,0.004047161,0.001090627,0.00845925,0.3826387,0.0008917141,0.01954549,0.3051825],"study_design_scores_gemma":[0.1079728,0.6978894,0.04338907,0.0001220354,0.001242109,0.006090652,0.0001593957,0.002670958,0.1110795,0.0004951138,0.02879062,0.00009856431],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767714,0.004377403,0.004580958,0.001222822,0.0001561445,0.003645615,0.004853215,0.0003953573,0.003996987],"genre_scores_gemma":[0.9733488,0.00355779,0.006194603,0.001479948,0.000148646,0.0027846,0.005865047,0.0001100514,0.006510509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002923179,"threshold_uncertainty_score":0.009779036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746789281397834,"score_gpt":0.2817679492890851,"score_spread":0.2643000564751067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}