{"id":"W2552600182","doi":"10.1182/blood.v116.21.3298.3298","title":"Phase I Trial Results for SL-401, a Novel Cancer Stem Cell (CSC) Targeting Agent, Demonstrate Clinical Efficacy at Tolerable Doses In Patients with Heavily Pre-Treated AML, Poor Risk Elderly AML, and High Risk MDS","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Internal medicine; Regimen; Stem cell; Oncology; Myeloid leukemia; Myelodysplastic syndromes; Phases of clinical research; Gastroenterology; Clinical trial; Pharmacology; Bone marrow; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005799527,0.0007725164,0.0007798575,0.0001875006,0.000221108,0.0003274094,0.0002869583,0.0004966067,0.002856292],"category_scores_gemma":[0.0003724044,0.0001648034,0.0003751162,0.0001610771,0.0004760886,0.000316439,0.0001533825,0.001314236,0.0005111217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003942318,"about_ca_system_score_gemma":0.0005356388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003591543,"about_ca_topic_score_gemma":0.001089929,"domain_scores_codex":[0.9998555,0.00005756852,0.00001086247,0.00002133078,0.00001627672,0.00003838007],"domain_scores_gemma":[0.9995764,0.00008889617,0.00007940715,0.00002765708,0.00001606352,0.0002116379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4846849,0.04948241,0.0392899,0.0006321671,0.0008805209,0.000824014,0.0005595949,0.006014635,0.197659,0.0006732279,0.00779723,0.2115025],"study_design_scores_gemma":[0.2385531,0.6749063,0.04863754,0.00005176324,0.0003669946,0.001033589,0.00008004549,0.00291323,0.02740671,0.0003309547,0.005682619,0.00003718509],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99708,0.0004590989,0.0003262957,0.0001512765,0.00001844891,0.0003659263,0.0002899401,0.00005271889,0.00125632],"genre_scores_gemma":[0.9957164,0.0003233497,0.0008514822,0.00020954,0.00005423283,0.0004725495,0.001084012,0.00001167732,0.001276766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002856292,"threshold_uncertainty_score":0.009555221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03173972585346042,"score_gpt":0.3395833302065079,"score_spread":0.3078436043530475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}