{"id":"W2552660438","doi":"10.1007/s11010-016-2886-8","title":"Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4","year":2016,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Manitoba; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Family Process Institute; Manitoba Medical Service Foundation","keywords":"RAC1; Agonist; Quinine; Cell biology; Chemistry; Pharmacology; Receptor; RHOA; GTPase; Biochemistry; Biology; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819701,0.0002224583,0.0002317467,0.0001558235,0.0003383849,0.0003135904,0.0002899772,0.0003129196,0.001953669],"category_scores_gemma":[0.0001986972,0.0001487826,0.0003443522,0.0001179875,0.0003081776,0.0003776131,0.0001907593,0.0004721594,0.0002762519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004659127,"about_ca_system_score_gemma":0.00022992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451064,"about_ca_topic_score_gemma":0.002223475,"domain_scores_codex":[0.9998183,0.00005046606,0.000009098409,0.00002496541,0.00002409309,0.00007323983],"domain_scores_gemma":[0.9999292,0.00001237923,0.00001753902,0.00001006668,0.00001326805,0.00001764151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001109956,0.00003675955,0.0001726372,0.00003522035,0.000006674014,0.0001114136,0.00003782925,0.00004836189,0.9971732,0.0003890583,0.00009327351,0.000785707],"study_design_scores_gemma":[0.0001778472,0.0004559984,0.01921951,0.00001314762,0.00003823245,0.0003763612,0.000248442,0.004908992,0.9707167,0.0002796734,0.003543332,0.00002183155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963996,0.0008842115,0.0005751362,0.000309726,0.00003137619,0.00001334209,0.0001323076,0.00002934173,0.001624916],"genre_scores_gemma":[0.9964334,0.0003991598,0.000517757,0.00006352358,0.000009666769,0.00001903246,0.0001098159,0.000009112997,0.002438662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001953669,"threshold_uncertainty_score":0.006535649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004510327636320602,"score_gpt":0.2054245799300096,"score_spread":0.200914252293689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}