{"id":"W2552675883","doi":"10.1074/jbc.m116.758185","title":"Phosphorylation of Human Retinoid X Receptor α at Serine 260 Impairs Its Subcellular Localization, Receptor Interaction, Nuclear Mobility, and 1α,25-Dihydroxyvitamin D3-dependent DNA Binding in Ras-transformed Keratinocytes","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Calcitriol receptor; Nuclear transport; Nuclear localization sequence; Nuclear receptor; Transfection; Retinoid X receptor; Chromatin; Phosphorylation; Subcellular localization; Biology; Cell biology; Serine; Fluorescence recovery after photobleaching; Molecular biology; Receptor; Mutant; Biochemistry; Cell nucleus; Transcription factor; DNA; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006854087,0.0002361786,0.0003592462,0.00004907262,0.00009060291,0.00002418861,0.0002670691,0.000410245,0.0003794876],"category_scores_gemma":[0.00043938,0.0001626352,0.0001376538,0.0001222108,0.0001790678,0.00002871992,0.00009627642,0.0001954459,0.000004255476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001331846,"about_ca_system_score_gemma":0.00005372608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002002401,"about_ca_topic_score_gemma":0.000001687909,"domain_scores_codex":[0.9981986,0.0001226359,0.000846424,0.0003544305,0.0002379515,0.000239984],"domain_scores_gemma":[0.9988364,0.00005972004,0.0005405517,0.0001870773,0.0002597573,0.0001165074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003383283,0.0001709,0.01483995,0.0001854242,0.00003516161,0.000007275681,0.00009583883,0.000009989073,0.9836125,0.000008661874,0.0002653852,0.0004306124],"study_design_scores_gemma":[0.001153663,0.0007521653,0.0006931535,0.0001694985,0.00001625315,0.00009678848,0.0003244798,0.00001295296,0.9935918,0.00003719514,0.00293701,0.0002150324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998366,0.0008264637,0.0002042892,0.0001185931,0.00008175046,0.0001355124,0.00002389552,0.000008650042,0.0002348237],"genre_scores_gemma":[0.9973725,0.001915451,0.0001607763,0.00002777178,0.0002009215,0.000006252997,0.00009936713,0.00001922529,0.000197729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01414679,"threshold_uncertainty_score":0.6632069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183228391784553,"score_gpt":0.2436783605184477,"score_spread":0.2318460766006021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}