{"id":"W2552675883","doi":"10.1074/jbc.m116.758185","title":"Phosphorylation of Human Retinoid X Receptor α at Serine 260 Impairs Its Subcellular Localization, Receptor Interaction, Nuclear Mobility, and 1α,25-Dihydroxyvitamin D3-dependent DNA Binding in Ras-transformed Keratinocytes","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Calcitriol receptor; Nuclear transport; Nuclear localization sequence; Nuclear receptor; Transfection; Retinoid X receptor; Chromatin; Phosphorylation; Subcellular localization; Biology; Cell biology; Serine; Fluorescence recovery after photobleaching; Molecular biology; Receptor; Mutant; Biochemistry; Cell nucleus; Transcription factor; DNA; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052505,0.0003172522,0.0002256079,0.0001314811,0.0001670027,0.0002326567,0.0002089883,0.0002057277,0.003465152],"category_scores_gemma":[0.00008435621,0.0001762448,0.0002875644,0.0001072761,0.0002900306,0.0001802114,0.0001126888,0.0005490122,0.0007894509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838834,"about_ca_system_score_gemma":0.000183612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007428232,"about_ca_topic_score_gemma":0.0005715856,"domain_scores_codex":[0.9998788,0.00002390138,0.00001746011,0.00002817652,0.00002488368,0.00002683658],"domain_scores_gemma":[0.9998914,0.00002183983,0.00002740823,0.00002284176,0.000004905166,0.00003166031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001699346,0.00002588348,0.00009313368,0.00002051395,0.00000592439,0.00006160406,0.0000149169,0.0000472611,0.9990892,0.0000893808,0.00001842534,0.0003637317],"study_design_scores_gemma":[0.00001726539,0.0002202124,0.003116098,0.000004226668,0.00001269174,0.000352875,0.00004366687,0.0003934316,0.9948099,0.00004871414,0.0009764489,0.000004487439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976571,0.0004765457,0.0007534417,0.00005017672,0.00003130698,0.000007731431,0.0002205625,0.0000367775,0.0007663576],"genre_scores_gemma":[0.995996,0.0003372834,0.0004928391,0.00001701499,0.000004602342,0.000009779726,0.0003780772,0.00001236308,0.002752012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003465152,"threshold_uncertainty_score":0.01159209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183228391784553,"score_gpt":0.2436783605184477,"score_spread":0.2318460766006021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}