{"id":"W2552678756","doi":"10.1182/blood.v110.11.547.547","title":"A Unique Pre-Clinical Model Providing Access to a Drug Resistant Population within the Multiple Myeloma Stem Cell Niche in a Novel 3-D Culture System for Bone Marrow.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Bone marrow; Stromal cell; Haematopoiesis; Stem cell; Biology; clone (Java method); Progenitor cell; Tumor microenvironment; Population; Cancer research; Immunology; Cell biology; Pathology; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002871573,0.0003704766,0.0002587474,0.0003739369,0.0003747688,0.0006231899,0.0005972699,0.0008163914,0.00222307],"category_scores_gemma":[0.0001113127,0.0002568181,0.0003618154,0.000259687,0.0002987786,0.0002056824,0.0003919496,0.001022278,0.0009940147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004865373,"about_ca_system_score_gemma":0.0005294023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003016947,"about_ca_topic_score_gemma":0.005667205,"domain_scores_codex":[0.999729,0.00004864596,0.00002362236,0.00005537875,0.0001076239,0.00003578492],"domain_scores_gemma":[0.9998073,0.00004328874,0.00003764866,0.00003763448,0.00002138316,0.00005284958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009996501,0.00008967841,0.000265325,0.00006851873,0.000005995339,0.0003140915,0.00005942721,0.0006556719,0.9962156,0.0006748421,0.0002770022,0.001273924],"study_design_scores_gemma":[0.00007977923,0.001155821,0.006389787,0.00004281317,0.00005117277,0.002513966,0.0001498799,0.01015277,0.9518015,0.0003941463,0.02723811,0.00003026865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9020584,0.004092588,0.07226972,0.001097611,0.0003615278,0.0005468714,0.004991683,0.0006805668,0.01390106],"genre_scores_gemma":[0.9298752,0.001599631,0.05491883,0.0003229186,0.00003732343,0.0004573654,0.002345531,0.00007113828,0.0103721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003016947,"threshold_uncertainty_score":0.007436931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06046261450685329,"score_gpt":0.3585497915231922,"score_spread":0.2980871770163389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}