{"id":"W2552832881","doi":"10.1038/srep36596","title":"Assessment of Circulating LncRNAs Under Physiologic and Pathologic Conditions in Humans Reveals Potential Limitations as Biomarkers","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; McGill University Health Centre; Ottawa Hospital","funders":"Actelion Pharmaceuticals; Core Research for Evolutional Science and Technology; Canadian Institutes of Health Research","keywords":"Biomarker; Long non-coding RNA; RNA; Biology; Molecular biomarkers; Coronary artery disease; Bioinformatics; Medicine; Computational biology; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003629404,0.0006450216,0.0007871246,0.0007764687,0.000384467,0.001554138,0.0005171628,0.0007970363,0.00112692],"category_scores_gemma":[0.005586337,0.0003043042,0.000296303,0.0007887463,0.001114699,0.0007908032,0.0004586857,0.0008311091,0.0004979292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003029746,"about_ca_system_score_gemma":0.0004711061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005482056,"about_ca_topic_score_gemma":0.0006472712,"domain_scores_codex":[0.9966009,0.001282334,0.0002806521,0.0009614958,0.0007375219,0.0001370683],"domain_scores_gemma":[0.9967312,0.001752827,0.0006085447,0.0003961543,0.0004032321,0.0001079493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001588662,0.0001881915,0.2269984,0.001597203,0.0004186089,0.0005049345,0.001066011,0.0008732139,0.6549199,0.002012772,0.00129137,0.1085406],"study_design_scores_gemma":[0.00007492263,0.00352196,0.4622135,0.0004481043,0.0008920975,0.004864399,0.001805771,0.009900496,0.4729807,0.01091375,0.03222109,0.0001631127],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8085012,0.05606129,0.1203755,0.00258682,0.0007563097,0.0002551537,0.003664016,0.0005403885,0.007259428],"genre_scores_gemma":[0.9581547,0.006445822,0.03056159,0.001303332,0.0003356895,0.0002967733,0.001058686,0.00008613794,0.001757238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003629404,"threshold_uncertainty_score":0.01919436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02656621427790914,"score_gpt":0.3234356264085108,"score_spread":0.2968694121306017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}