{"id":"W2553022533","doi":"10.3389/fphar.2016.00446","title":"Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator","year":2016,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institutes of Health; Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja","keywords":"GABAA receptor; Allosteric regulation; Allosteric modulator; Protein subunit; Pharmacology; Receptor; GABAA-rho receptor; Chemistry; Cell biology; Medicine; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000755841,0.0003271858,0.0006551626,0.0005931254,0.0001721059,0.00002432233,0.001002615,0.0001572052,0.0003087821],"category_scores_gemma":[0.0002921474,0.0002476804,0.00009638632,0.0005787261,0.0009561376,0.0005805527,0.0003157092,0.0004677785,0.00004914782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000139887,"about_ca_system_score_gemma":0.0001144168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001058888,"about_ca_topic_score_gemma":0.000001143051,"domain_scores_codex":[0.994477,0.002607859,0.0004697559,0.0010267,0.0004605331,0.0009581097],"domain_scores_gemma":[0.998168,0.0009744101,0.000215234,0.0002925171,0.0000578915,0.0002919442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001713955,0.0002560515,0.03406855,0.00002765613,0.00001673528,0.0005702251,0.0001708617,0.00003228316,0.9553143,0.000009260227,0.0009591611,0.006860971],"study_design_scores_gemma":[0.004263434,0.002367256,0.001605655,0.0000243402,0.00003136639,0.00005907942,0.00003865341,0.0009135614,0.9900858,0.00002663523,0.0003301775,0.0002540426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993618,0.00005892973,0.0001732703,0.0004416567,0.004347982,0.0008859794,0.0001853148,0.00007484326,0.0002140562],"genre_scores_gemma":[0.9975196,0.0003220573,0.00005574428,0.001060362,0.000142939,0.0001061254,0.000001787794,0.00004586031,0.0007455693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03477151,"threshold_uncertainty_score":0.9999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181873293035693,"score_gpt":0.3312293728010834,"score_spread":0.3094106398707265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}