{"id":"W2553053943","doi":"10.1038/nature20578","title":"Inhibition of mTOR induces a paused pluripotent state","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":289,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Centre for Phenogenomics","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Science Foundation; National Institutes of Health; National Cancer Institute; University of California, San Francisco","keywords":"Induced pluripotent stem cell; Blastocyst; Embryonic stem cell; Cell biology; Biology; Epiblast; PI3K/AKT/mTOR pathway; Stem cell; Inner cell mass; Embryo; Genetics; Embryogenesis; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001476156,0.00009263731,0.00009468864,0.0000509514,0.00002428456,0.000006484496,0.0001229186,0.0005661049,0.00003372413],"category_scores_gemma":[0.000102119,0.00005991858,0.00005857272,0.00007710977,0.0000607426,0.000003928398,0.00009562552,0.0002823502,0.00001926295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001552449,"about_ca_system_score_gemma":0.00005989045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000331184,"about_ca_topic_score_gemma":0.00001086461,"domain_scores_codex":[0.9991547,0.00004953907,0.0001335176,0.0002322649,0.000239077,0.0001909268],"domain_scores_gemma":[0.9994799,0.00001236404,0.00006477891,0.0002411342,0.0001397688,0.00006200968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009001999,0.00003785678,0.000327654,0.00002015802,0.00002585309,0.00000514071,0.00001558758,0.00000159197,0.9917541,0.00001829725,0.002830748,0.004873038],"study_design_scores_gemma":[0.0005990635,0.0001576506,0.003201655,0.00004040952,0.000003854908,0.000004128032,0.000008419709,0.000001501801,0.9763132,0.0001308691,0.01944953,0.00008972063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997296,0.0007309324,0.0001501163,0.0007110058,0.0001003544,0.000140715,0.00007311624,0.000008553659,0.0007892215],"genre_scores_gemma":[0.996699,0.0002570814,0.0001192474,0.0001501489,0.000100808,0.000009294474,0.00003640847,0.00001373067,0.002614326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01661878,"threshold_uncertainty_score":0.4366319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009196603105427354,"score_gpt":0.2613024699514857,"score_spread":0.2521058668460583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}