{"id":"W2553053943","doi":"10.1038/nature20578","title":"Inhibition of mTOR induces a paused pluripotent state","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":289,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Centre for Phenogenomics","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Science Foundation; National Institutes of Health; National Cancer Institute; University of California, San Francisco","keywords":"Induced pluripotent stem cell; Blastocyst; Embryonic stem cell; Cell biology; Biology; Epiblast; PI3K/AKT/mTOR pathway; Stem cell; Inner cell mass; Embryo; Genetics; Embryogenesis; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002711996,0.0002571476,0.0003119834,0.0003326376,0.0001912091,0.000639721,0.0003262491,0.0003649352,0.003659613],"category_scores_gemma":[0.0002853693,0.0002229259,0.0003830003,0.0001840783,0.0002561099,0.0002293989,0.0004078508,0.001074243,0.0007960674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003176693,"about_ca_system_score_gemma":0.0001908337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002066103,"about_ca_topic_score_gemma":0.0004594487,"domain_scores_codex":[0.9997911,0.00002887124,0.00003127692,0.00005141371,0.00005184527,0.00004553256],"domain_scores_gemma":[0.9996477,0.0001342421,0.00006999173,0.00005516436,0.00002036912,0.00007253176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002120232,0.00004092702,0.0001947615,0.00004279138,0.00001995058,0.0001585759,0.00003380206,0.0001862743,0.9936458,0.001742528,0.0003531111,0.003369474],"study_design_scores_gemma":[0.00004196586,0.0001905852,0.00195846,0.000009143508,0.00002405456,0.0002786515,0.00002473559,0.001226305,0.9895335,0.0003158637,0.006389706,0.000006985737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666494,0.003099916,0.01286613,0.0005969474,0.0003877614,0.0000886325,0.003067374,0.0009464183,0.01229743],"genre_scores_gemma":[0.9917758,0.000425545,0.001837591,0.0002120118,0.00002649333,0.00004284679,0.0009523361,0.0001346165,0.004592668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003659613,"threshold_uncertainty_score":0.01224262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009196603105427354,"score_gpt":0.2613024699514857,"score_spread":0.2521058668460583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}