{"id":"W2553056070","doi":"10.1038/ncomms13516","title":"Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Montréal; Hôpital Maisonneuve-Rosemont; St. Michael's Hospital","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; Yale Liver Center; National Institute on Aging; Pfizer","keywords":"Transcytosis; LDL receptor; Endocytic cycle; Endothelium; Cell biology; Endocytosis; PCSK9; Biology; Endothelial dysfunction; Probucol; Receptor; Lipoprotein; Chemistry; Biochemistry; Cholesterol; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002797145,0.0003906435,0.0003857311,0.0004551723,0.000290843,0.0004359903,0.0003153524,0.0004556331,0.001729704],"category_scores_gemma":[0.0001845326,0.0002472466,0.0004313773,0.0002932872,0.0002233116,0.0001345551,0.0002890597,0.0005550669,0.0006877735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003210491,"about_ca_system_score_gemma":0.0003095675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001494196,"about_ca_topic_score_gemma":0.003210605,"domain_scores_codex":[0.9997703,0.00002619343,0.000022797,0.00007330746,0.00006911396,0.00003823692],"domain_scores_gemma":[0.9998029,0.00005775179,0.00006394125,0.0000233248,0.00002042123,0.00003175438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001143251,0.00001899498,0.0007956165,0.00006237176,0.00003164934,0.0001452454,0.00001547604,0.0001626257,0.9959893,0.0001926256,0.0001909018,0.002280816],"study_design_scores_gemma":[0.00007208431,0.0001865093,0.02199917,0.00002105534,0.0002698849,0.0007525311,0.00005643822,0.004643736,0.9618685,0.0001888019,0.009917168,0.00002398466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763963,0.002107113,0.01185247,0.0002777671,0.0000623507,0.00005416172,0.005601375,0.0006894183,0.002959054],"genre_scores_gemma":[0.9819665,0.001392219,0.005792442,0.0002388725,0.00001205174,0.00007371877,0.005712566,0.0001618658,0.004649865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729704,"threshold_uncertainty_score":0.005786419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032248418892981,"score_gpt":0.2498593505103603,"score_spread":0.2395368663214305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}