{"id":"W2553059833","doi":"10.1016/j.cell.2016.10.026","title":"Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":779,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; Max-Planck-Gesellschaft; Lundbeckfonden; Ministerio de Economía y Competitividad; NIHR Cambridge Biomedical Research Centre; European Commission; University of Cambridge; European Molecular Biology Laboratory; University of Oxford; NHS Blood and Transplant; McGill University; European Bioinformatics Institute; National Institute for Health and Care Research; Genome Canada; British Heart Foundation; Wellcome Trust","keywords":"Biology; Epigenetics; Quantitative trait locus; DNA methylation; Expression quantitative trait loci; Epigenome; Genetics; Genome-wide association study; Epigenomics; Allele; Histone; Genetic variation; Computational biology; Gene; Gene expression; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120927,0.00007111482,0.0001383613,0.0004464909,0.0002028983,0.0002180609,0.000107064,0.000125097,0.002624299],"category_scores_gemma":[0.0002825548,0.00008756001,0.0001010295,0.0005493378,0.0001245265,0.000058613,0.0002205904,0.0001702306,0.0003652437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001219606,"about_ca_system_score_gemma":0.0001008037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008026126,"about_ca_topic_score_gemma":0.001959396,"domain_scores_codex":[0.9998806,0.00002057648,0.000007542208,0.00004111712,0.00002940658,0.0000207643],"domain_scores_gemma":[0.9999022,0.0000273646,0.00002145919,0.00001886088,0.00001318926,0.00001683459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001142053,0.0001121076,0.2243541,0.0001168451,0.0002363487,0.0008000525,0.0004170642,0.0009484834,0.7229938,0.001547665,0.001009754,0.04632181],"study_design_scores_gemma":[0.00003690423,0.0002677296,0.9109816,0.0000160309,0.0001429871,0.002757671,0.000277802,0.0009602068,0.07299353,0.001036183,0.01051432,0.00001512046],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944873,0.0004267537,0.001641203,0.00003535566,0.000007361571,0.00001565884,0.001868804,0.00001876907,0.001498842],"genre_scores_gemma":[0.9958209,0.0002214062,0.000779932,0.00003353494,0.000008026051,0.00002354771,0.001625481,0.00001037753,0.001476795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002624299,"threshold_uncertainty_score":0.008779168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006209911734211974,"score_gpt":0.2096002954075117,"score_spread":0.2033903836732998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}