{"id":"W2553059833","doi":"10.1016/j.cell.2016.10.026","title":"Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":779,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; Max-Planck-Gesellschaft; Lundbeckfonden; Ministerio de Economía y Competitividad; NIHR Cambridge Biomedical Research Centre; European Commission; University of Cambridge; European Molecular Biology Laboratory; University of Oxford; NHS Blood and Transplant; McGill University; European Bioinformatics Institute; National Institute for Health and Care Research; Genome Canada; British Heart Foundation; Wellcome Trust","keywords":"Biology; Epigenetics; Quantitative trait locus; DNA methylation; Expression quantitative trait loci; Epigenome; Genetics; Genome-wide association study; Epigenomics; Allele; Histone; Genetic variation; Computational biology; Gene; Gene expression; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026561,0.00007532956,0.00008492202,0.00004825457,0.00002237044,0.00000414998,0.00006271023,0.00008819304,0.00003217644],"category_scores_gemma":[0.000006432118,0.00006450462,0.00003425954,0.00003980116,0.00005405873,0.000002099901,0.00002042247,0.00002237827,0.000002426358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007830753,"about_ca_system_score_gemma":0.00001972152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002685173,"about_ca_topic_score_gemma":0.00001962309,"domain_scores_codex":[0.999398,0.00004207361,0.0001984745,0.000184039,0.00007073591,0.0001066792],"domain_scores_gemma":[0.9997188,0.000009190667,0.00006395725,0.0001411567,0.00003433255,0.00003253197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009098837,0.0000359314,0.00389182,0.00001232071,0.000004610413,3.219557e-7,0.00008149771,0.00008092734,0.9947928,0.00005148003,0.000003773455,0.001035418],"study_design_scores_gemma":[0.0005252348,0.0001153284,0.2526426,0.000007963656,0.000006568167,1.814026e-7,0.000006871206,0.00001224214,0.7456805,0.00039036,0.0005432544,0.00006894062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885435,0.001913503,0.008841032,0.00002451081,0.00006253338,0.00009715804,0.00001126765,0.000002129884,0.0005043425],"genre_scores_gemma":[0.9977554,0.0008936903,0.0009341422,0.000007548532,0.00003857864,0.000004347716,0.00001044696,0.000009861552,0.0003459781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2491123,"threshold_uncertainty_score":0.2630422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006209911734211974,"score_gpt":0.2096002954075117,"score_spread":0.2033903836732998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}