{"id":"W2553077423","doi":"10.1182/blood.v116.21.138.138","title":"Studies of BP-1-102, a Novel Direct Small-Molecule Inhibitor of Stat3 Demonstrates Substantial Anti-Myeloma Pre-Clinical Activity","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"STAT3; Angiogenesis; Cell biology; Chemistry; Biology; SH2 domain; Cancer research; Phosphopeptide; Phosphorylation; Tyrosine phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673552,0.0003519144,0.0002556332,0.000141243,0.0001011844,0.0001273207,0.0001983379,0.0002216373,0.001695838],"category_scores_gemma":[0.00009320013,0.0001160432,0.0001876974,0.0001170222,0.0001285826,0.0001131746,0.00006627323,0.0006297106,0.0005218422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984168,"about_ca_system_score_gemma":0.0002215619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003929021,"about_ca_topic_score_gemma":0.0007657756,"domain_scores_codex":[0.9999275,0.00001217488,0.00000379852,0.00001027312,0.00002626581,0.00002001988],"domain_scores_gemma":[0.9999473,0.00001236848,0.00001043075,0.00000344802,0.000007984649,0.00001840101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003582532,0.0004425267,0.0001409165,0.00006060332,0.00001261749,0.00004994458,0.00001102493,0.0003994365,0.9938837,0.00007509226,0.0001455822,0.004420305],"study_design_scores_gemma":[0.000326629,0.009155205,0.003498911,0.000005771811,0.00004608546,0.000520199,0.000008446448,0.002641233,0.9794751,0.00003783869,0.004277429,0.000007068163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989111,0.004105222,0.002814596,0.0001854038,0.00005745679,0.0001265065,0.0004336849,0.0001085021,0.003057509],"genre_scores_gemma":[0.9926695,0.001709859,0.001790239,0.00009816227,0.00001585267,0.00005577213,0.001098898,0.00001282004,0.002548975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695838,"threshold_uncertainty_score":0.00567317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06712066682499301,"score_gpt":0.3767105163406372,"score_spread":0.3095898495156442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}