{"id":"W2553082272","doi":"10.1136/annrheumdis-2016-eular.1448","title":"AB0390 Safety and Efficacy of ABT-494, A Novel Selective JAK1 Inhibitor, in Patients with Active Rheumatoid Arthritis and Inadequate Response or Intolerance To Anti-TNF Biologic Therapy","year":2016,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Medicine; Rheumatoid arthritis; TNF inhibitor; Internal medicine; Methotrexate; Placebo; Clinical endpoint; Gastroenterology; Pharmacology; Tumor necrosis factor alpha; Randomized controlled trial; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008979,0.0003798413,0.001040801,0.0003432161,0.0002470227,0.0006250255,0.0002844878,0.0005452624,0.0009722554],"category_scores_gemma":[0.001748701,0.0001804571,0.0006978388,0.0003505928,0.0003456265,0.00053945,0.0001498427,0.001407773,0.0003537037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004482278,"about_ca_system_score_gemma":0.0004186416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007321474,"about_ca_topic_score_gemma":0.001160263,"domain_scores_codex":[0.9995895,0.0001511836,0.00005102794,0.00005382418,0.00008279856,0.0000717134],"domain_scores_gemma":[0.9990428,0.0003507687,0.0002198094,0.00007007857,0.00006645304,0.0002500313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4172377,0.00701469,0.2137832,0.0005520479,0.002624256,0.003501268,0.0003466893,0.003158756,0.06242518,0.0004575247,0.003518835,0.2853798],"study_design_scores_gemma":[0.05369467,0.1975374,0.7101856,0.0001603994,0.002757566,0.008246853,0.0002378081,0.007777382,0.01113479,0.0006567544,0.007499163,0.000111552],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919707,0.005352979,0.0001522373,0.0002996151,0.00007386054,0.00003295922,0.0002544171,0.00002490447,0.001838272],"genre_scores_gemma":[0.9984815,0.0007108698,0.00006967146,0.00018863,0.00008255232,0.000008741488,0.0002516608,0.000003718014,0.0002025987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040801,"threshold_uncertainty_score":0.004748583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02057804667354315,"score_gpt":0.2751909860103811,"score_spread":0.2546129393368379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}