{"id":"W2553090955","doi":"10.1186/s13063-016-1689-2","title":"A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial","year":2016,"lang":"en","type":"article","venue":"Trials","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University; St. Joseph’s Healthcare Hamilton; McMaster Children's Hospital","funders":"Canadian Institutes of Health Research; Hamilton Health Sciences; Groupe canadien de recherche en soins intensifs; Canadian Child Health Clinician Scientist Program; Canadian Blood Services; McMaster University","keywords":"Medicine; Randomized controlled trial; Resuscitation; Septic shock; Protocol (science); Intensive care medicine; Clinical trial; Randomization; Emergency medicine; Sepsis; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01392494,0.005355523,0.007991407,0.001465889,0.00132329,0.002914418,0.002611178,0.005541431,0.02735184],"category_scores_gemma":[0.02064223,0.001798195,0.004629964,0.001307727,0.003094226,0.003629533,0.001534415,0.004862119,0.003610237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002136178,"about_ca_system_score_gemma":0.005409524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001394411,"about_ca_topic_score_gemma":0.001882207,"domain_scores_codex":[0.9898615,0.00687546,0.0006847992,0.001054635,0.0006154585,0.0009081672],"domain_scores_gemma":[0.9906344,0.004009703,0.002190869,0.0008982594,0.0009567978,0.001310036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.987911,0.003467263,0.0002458979,0.001733277,0.001001346,0.0000474372,0.00005942761,0.0003239321,0.0005048012,0.0004844358,0.00104812,0.003173091],"study_design_scores_gemma":[0.9799699,0.0181591,0.0002030482,0.00009665799,0.0002670315,0.00001047575,0.00001489613,0.000331434,0.0000817543,0.0002771619,0.0005767514,0.00001169404],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1130288,0.00242576,0.005051923,0.001872069,0.003001076,0.8672121,0.003413311,0.0005539419,0.003441052],"genre_scores_gemma":[0.09044347,0.000863331,0.008877248,0.0015304,0.0005861811,0.8946464,0.000735137,0.00003606764,0.002281739],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02735184,"threshold_uncertainty_score":0.091501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1689172232685373,"score_gpt":0.4394525657751506,"score_spread":0.2705353425066133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}