{"id":"W2553096850","doi":"10.1182/blood.v116.21.576.576","title":"The Reduced Lymphopoietic Potential of a Novel Subclass of Hematopoietic Stem Cells Is Mediated by Specific Defects In the Production and Activity of Their Common Lymphoid Progenitor (CLP) Progeny","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Terry Fox Research Institute","funders":"","keywords":"Haematopoiesis; Biology; Stem cell; Bone marrow; Progenitor cell; Myeloid; Immunology; Population; Cell biology; Lymphopoiesis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000161947,0.0003061599,0.0002116213,0.0004030389,0.00007299105,0.0002196148,0.000222293,0.0001683393,0.001242462],"category_scores_gemma":[0.000152078,0.0001219426,0.0001991598,0.0001060133,0.0002692447,0.0001345163,0.0002481851,0.0003488889,0.0002824296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001478152,"about_ca_system_score_gemma":0.0001116777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002327044,"about_ca_topic_score_gemma":0.0002454418,"domain_scores_codex":[0.9998482,0.00001961221,0.00001954692,0.00003910837,0.00004134289,0.00003208104],"domain_scores_gemma":[0.9997799,0.00003718667,0.00006679152,0.00003061125,0.0000142418,0.00007144967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001147584,0.00001380999,0.0007664708,0.00001145859,0.000003932455,0.0000556697,0.00001042522,0.00002845245,0.9979939,0.00009180693,0.000015121,0.0008941932],"study_design_scores_gemma":[0.00003097741,0.0007766347,0.03161671,0.0000110101,0.00004175811,0.001524114,0.00006112528,0.001121729,0.9626204,0.0001046708,0.002085214,0.00000561111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979393,0.0004252723,0.0009598762,0.00001579743,0.000006085181,0.00001043135,0.0001709012,0.00004843284,0.0004239753],"genre_scores_gemma":[0.9976761,0.0002993991,0.0003889814,0.00001558762,0.000005471921,0.00001846064,0.0003418267,0.00001987622,0.001234326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242462,"threshold_uncertainty_score":0.004156411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361600778926229,"score_gpt":0.2306202192572777,"score_spread":0.2170042114680154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}