{"id":"W2553106647","doi":"10.1038/srep37052","title":"Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Science and Technology Planning Project; National Natural Science Foundation of China","keywords":"Programmed cell death; Autophagy; Cancer research; Apoptosis; Cytotoxicity; Puma; Cyclin D1; Bafilomycin; MAPK/ERK pathway; Cell growth; Downregulation and upregulation; Cell cycle checkpoint; Cell cycle; Biology; Chemistry; Kinase; Cell biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001274718,0.0002324008,0.0004357984,0.0003171234,0.0001172242,0.00004004671,0.0001038075,0.0001389468,0.0002381215],"category_scores_gemma":[0.00005629081,0.0001640126,0.0001233411,0.0002970719,0.0001998613,0.0001568994,0.00009379102,0.0001342516,0.00001943712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008993057,"about_ca_system_score_gemma":0.0003154692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001507809,"about_ca_topic_score_gemma":0.000006016067,"domain_scores_codex":[0.9972244,0.00007438727,0.0007931481,0.0008409194,0.0006284245,0.0004387542],"domain_scores_gemma":[0.9983685,0.00005531411,0.0004080329,0.0007405211,0.0001399681,0.000287671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003669154,0.0004717824,0.1029987,0.0001152601,0.00001608349,0.005350757,0.0005418851,8.666634e-7,0.8889894,0.0000278846,0.0003362281,0.001114438],"study_design_scores_gemma":[0.00154404,0.00009877182,0.03339449,0.0001414319,0.00004075075,0.0002099429,0.0001055028,0.0001790284,0.9615877,0.001987716,0.0005236583,0.0001869863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953269,0.001603581,0.000131416,0.00004136872,0.001529624,0.0005313239,0.000008040382,0.00004405257,0.0007836582],"genre_scores_gemma":[0.9979867,0.00002908358,0.0003703882,0.00003249589,0.00007182993,0.00002222913,0.00002068987,0.00002961828,0.001436925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07259827,"threshold_uncertainty_score":0.668824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694199876168554,"score_gpt":0.231407049641191,"score_spread":0.2144650508795054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}