{"id":"W2553114211","doi":"10.1182/blood.v126.23.2580.2580","title":"Clinical Response to Idasanutlin (RG7388) in Acute Myeloid Leukemia Patients Is Associated with Pre-Treatment MDM2 Protein Expression in Leukemic Blasts and Leukemic Stem Cells","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Jewish General Hospital","funders":"","keywords":"Medicine; Cytarabine; Myeloid leukemia; Mdm2; Leukemia; Minimal residual disease; Internal medicine; Stem cell; Cancer research; Oncology; Immunology; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008390733,0.0002551214,0.0006042467,0.0002909343,0.0001587745,0.0004737882,0.0002541581,0.0003145207,0.001731315],"category_scores_gemma":[0.001154038,0.0001047637,0.0003517301,0.0002783269,0.0002175925,0.0001825841,0.0001997706,0.0004719608,0.0004261303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003151817,"about_ca_system_score_gemma":0.000314951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003692465,"about_ca_topic_score_gemma":0.0008111472,"domain_scores_codex":[0.9996201,0.0001105506,0.00004555196,0.00008455684,0.00009294593,0.00004634017],"domain_scores_gemma":[0.9994091,0.0002382623,0.0001493817,0.00004734489,0.00005459039,0.0001013876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0332272,0.001669556,0.7622212,0.0004137575,0.0006026201,0.000315154,0.0001243953,0.003764987,0.1029536,0.0001745089,0.003479465,0.09105356],"study_design_scores_gemma":[0.001507031,0.01114352,0.9408246,0.00007469405,0.0005717717,0.00145671,0.0001446947,0.006979859,0.03166438,0.0003326966,0.005265911,0.00003410346],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972277,0.0005058643,0.0002170566,0.00006744555,0.000007766383,0.00004861795,0.001308833,0.00002281927,0.0005937504],"genre_scores_gemma":[0.9951503,0.0002105891,0.0003698785,0.00006089906,0.000008175587,0.0000732487,0.00383985,0.000003662396,0.0002833827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001731315,"threshold_uncertainty_score":0.005791783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02626953709703774,"score_gpt":0.307679037739462,"score_spread":0.2814095006424243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}