{"id":"W2553143951","doi":"10.1182/blood.v116.21.3031.3031","title":"Baseline Peripheral Neuropathy Does Not Impact the Efficacy and Tolerability of the Novel Proteasome Inhibitor Carfilzomib (CFZ): Results of a Subset Analysis of a Phase 2 Trial In Patients with Relapsed and Refractory Multiple Myeloma (R/R MM)","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Calgary; Princess Margaret Cancer Centre","funders":"","keywords":"Carfilzomib; Tolerability; Medicine; Bortezomib; Proteasome inhibitor; Peripheral neuropathy; Adverse effect; Internal medicine; Multiple myeloma; Clinical trial; Thalidomide; Lenalidomide; Pharmacology; Oncology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002798193,0.0008353613,0.001777441,0.0002536183,0.000373519,0.0007845661,0.0004673909,0.0006566306,0.001929429],"category_scores_gemma":[0.001524863,0.0003083475,0.001354909,0.000377623,0.0005143044,0.0006592071,0.0002784068,0.001476223,0.0003449644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007633592,"about_ca_system_score_gemma":0.0008036826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009396404,"about_ca_topic_score_gemma":0.002476251,"domain_scores_codex":[0.9992313,0.0004138229,0.00005130247,0.0001170314,0.00007137336,0.0001151154],"domain_scores_gemma":[0.998888,0.0002926334,0.0002830923,0.00009793489,0.00007870798,0.0003597442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7930127,0.01575834,0.06859609,0.0005052667,0.003514721,0.0004630318,0.0003558595,0.00187213,0.03245055,0.00009209307,0.002182131,0.08119703],"study_design_scores_gemma":[0.2303323,0.51155,0.2437929,0.00004713787,0.003375764,0.001243917,0.0001578479,0.002070666,0.004640926,0.0001846443,0.002546312,0.00005758107],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977787,0.0008348913,0.0001311927,0.0001114698,0.0000147041,0.0002686721,0.0004213722,0.00001411691,0.0004247125],"genre_scores_gemma":[0.9979967,0.0002834532,0.0002424152,0.0001430632,0.00003496035,0.000169836,0.000829874,0.000007071535,0.0002925073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002798193,"threshold_uncertainty_score":0.01479846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405171240564668,"score_gpt":0.2827785638905845,"score_spread":0.2687268514849379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}