{"id":"W2553187720","doi":"10.1182/blood.v116.21.3985.3985","title":"Identification of AML and MDS Patients Who Could Potentially Benefit From Temozolomide Therapy: Proportion of Patients with Low Methyl Guanine Methyltransferase (MGMT) Expression Level","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); McMaster University Medical Centre; London Health Sciences Centre; Collège de Maisonneuve; Princess Margaret Cancer Centre","funders":"","keywords":"Temozolomide; Methyltransferase; O-6-methylguanine-DNA methyltransferase; Myeloid leukemia; Methylation; Medicine; Cancer research; Oncology; Leukemia; Decitabine; DNA methylation; Cytarabine; DNA methyltransferase; Bone marrow; Chemotherapy; Internal medicine; Biology; Gene expression; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203905,0.0001416051,0.0002181027,0.0003837918,0.00018151,0.0002909651,0.00009756718,0.0002137092,0.002407499],"category_scores_gemma":[0.0003965788,0.00009188527,0.0001209514,0.0002294172,0.0001190424,0.0002463296,0.0002018871,0.0001708694,0.000299177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008281275,"about_ca_system_score_gemma":0.00008117629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003689655,"about_ca_topic_score_gemma":0.0004872546,"domain_scores_codex":[0.9999362,0.000009982547,0.000007326939,0.00002160819,0.00001101144,0.00001399929],"domain_scores_gemma":[0.9998249,0.00002813318,0.00006086069,0.000005453448,0.00001518883,0.00006549761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004643599,0.00004380736,0.9924516,0.00000882625,0.00001222268,0.0001764791,0.00003972299,0.0000490543,0.003679678,0.00001844671,0.00009873234,0.002957074],"study_design_scores_gemma":[0.00002426865,0.0002898787,0.9975061,0.000004003001,0.00002239576,0.0008664246,0.0001195055,0.0003309152,0.0004896746,0.00003589943,0.0003076481,0.000003417492],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996408,0.00007883862,0.00004905965,0.00001693199,0.000001352494,0.000004581131,0.00007307198,0.000001970023,0.0001333502],"genre_scores_gemma":[0.9996489,0.0000314435,0.00006014317,0.0000138563,0.000005939292,0.000005179765,0.0001141471,7.684106e-7,0.0001195574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002407499,"threshold_uncertainty_score":0.008053839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01095199029368456,"score_gpt":0.2538591363813201,"score_spread":0.2429071460876355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}