{"id":"W2553187946","doi":"10.1182/blood.v118.21.278.278","title":"Consistent Benefit of Ruxolitinib Over Placebo in Spleen Volume Reduction and Symptom Improvement Across Subgroups and Overall Survival Advantage: Results From COMFORT-I","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ruxolitinib; Medicine; Myelofibrosis; Placebo; Internal medicine; Gastroenterology; Surgery; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001911744,0.0008222994,0.002328353,0.0002460432,0.0002200178,0.0007147487,0.0004230491,0.0008592297,0.005601982],"category_scores_gemma":[0.00194616,0.0002248923,0.002811108,0.0002989045,0.0004896347,0.0007328259,0.0004416822,0.001404077,0.0004090768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004433968,"about_ca_system_score_gemma":0.0005243156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003065779,"about_ca_topic_score_gemma":0.0006204445,"domain_scores_codex":[0.9990263,0.0004884902,0.0001238487,0.0001649228,0.00008133108,0.0001150631],"domain_scores_gemma":[0.9987451,0.0004203542,0.0003711375,0.0001467666,0.00007200264,0.000244642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9534214,0.003394125,0.002592315,0.000468792,0.001698816,0.00002802136,0.00003265598,0.0003734597,0.007349209,0.00006613061,0.0005648823,0.03001013],"study_design_scores_gemma":[0.3931379,0.5439896,0.0481161,0.0001145096,0.004838218,0.0002048218,0.0001149755,0.001204162,0.005743113,0.0003556359,0.002126506,0.00005452797],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914079,0.00392442,0.0004999725,0.0002561974,0.00009700371,0.0005977862,0.001480637,0.00006140247,0.001674622],"genre_scores_gemma":[0.9965385,0.000640715,0.0004903688,0.0002727846,0.0001335746,0.0004306261,0.0009490087,0.00000860844,0.0005359154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005601982,"threshold_uncertainty_score":0.01874048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02270460961061386,"score_gpt":0.2660786291448861,"score_spread":0.2433740195342723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}