{"id":"W2553559912","doi":"10.1182/blood.v108.11.5472.5472","title":"Ex Vivo Gene Therapy for Haemophilia A: FVIII-Overexpressing Mesenchymal Stromal Cells Fail To Produce Sustained Therapeutic Levels of Circulating FVIII In Vivo.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; Jewish General Hospital","funders":"","keywords":"Ex vivo; Mesenchymal stem cell; Genetic enhancement; Stromal cell; Immunology; Medicine; Bone marrow; In vivo; Cancer research; Progenitor cell; Cell therapy; Stem cell; Biology; Pathology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000281894,0.0002193004,0.0002527461,0.0002021495,0.00009069854,0.0003315835,0.0001489779,0.0003196455,0.001285341],"category_scores_gemma":[0.0001315606,0.0001079301,0.0001986977,0.000106106,0.0002648717,0.00019142,0.00007889353,0.0005158487,0.0003871268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000157339,"about_ca_system_score_gemma":0.0001251254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003476531,"about_ca_topic_score_gemma":0.0004508503,"domain_scores_codex":[0.9998404,0.0000373603,0.00001592625,0.00002287338,0.00006194021,0.00002145221],"domain_scores_gemma":[0.999871,0.00004316123,0.00003468727,0.00001715511,0.00001200434,0.00002193247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007886648,0.00005133085,0.0001042557,0.00002503167,0.000005118422,0.00002757743,0.00001210697,0.00004900855,0.9984568,0.00007126834,0.00002724895,0.001091287],"study_design_scores_gemma":[0.00002557931,0.001301879,0.001467629,0.000004368199,0.0000225918,0.0003290777,0.00001541217,0.0006146328,0.9943152,0.00003088112,0.001869713,0.000002895028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942285,0.001022919,0.003567608,0.00008265632,0.0000370112,0.0000509846,0.0001678417,0.00006219586,0.0007803478],"genre_scores_gemma":[0.9942099,0.0006194185,0.003094777,0.00003476779,0.000009190005,0.00004035008,0.0002942733,0.00001693224,0.001680344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285341,"threshold_uncertainty_score":0.004299879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03810474012376936,"score_gpt":0.3060307845554628,"score_spread":0.2679260444316935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}