{"id":"W2553582313","doi":"10.1182/blood.v116.21.2497.2497","title":"Combinations of Epigenetic Modifying Agents Accentuate Retinoid-Mediated Gene Expression Over Single Agent Therapies In Acute Myelogenous Leukemia Cells","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre; Hamilton Health Sciences","funders":"","keywords":"Epigenetics; Cancer research; Epigenetic therapy; Histone deacetylase; Biology; Acute promyelocytic leukemia; DNA methylation; Decitabine; Retinoic acid; Tretinoin; Histone deacetylase inhibitor; Histone; Leukemia; Hypomethylating agent; Molecular biology; Gene expression; Cell culture; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272551,0.0001747038,0.0003734398,0.000192648,0.000118062,0.0002813114,0.0001593018,0.0001175959,0.00246137],"category_scores_gemma":[0.00009770814,0.00009048768,0.0002402419,0.000250228,0.0001502103,0.0001038054,0.0001864635,0.0003403753,0.0005497893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001723624,"about_ca_system_score_gemma":0.0001476329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002568235,"about_ca_topic_score_gemma":0.0008606082,"domain_scores_codex":[0.9997948,0.00002049121,0.00002083503,0.00005061178,0.00008090702,0.00003235622],"domain_scores_gemma":[0.9999356,0.00001527874,0.00001339031,0.00001436253,0.00001069197,0.00001067027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009296576,0.00003280392,0.0002920248,0.00004634219,0.000007863058,0.0000159906,0.00001261074,0.00005933738,0.9961082,0.00004207795,0.00009195587,0.003197832],"study_design_scores_gemma":[0.00002105153,0.000540281,0.004703591,0.000005772362,0.000028964,0.0001101394,0.00002464269,0.0003693325,0.9878185,0.00003245203,0.006341587,0.000003667436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986025,0.003719601,0.003757463,0.0001187915,0.00006691978,0.00009890763,0.001209829,0.0001909426,0.004812544],"genre_scores_gemma":[0.9842699,0.002321449,0.006368103,0.00009873608,0.00003040548,0.0001634733,0.001328437,0.00003286606,0.005386743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00246137,"threshold_uncertainty_score":0.008234143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040329619554679,"score_gpt":0.2370945438492383,"score_spread":0.2266912476536915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}