{"id":"W2553590829","doi":"10.2196/resprot.6610","title":"A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS)","year":2016,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Peripheral Neuropathies and Disorders","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Eculizumab; Medicine; Guillain-Barre syndrome; Complement system; Immunology; Flaccid paralysis; Clinical trial; Antibody; Internal medicine; Paralysis; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008141364,0.003684783,0.004287856,0.0005934632,0.001231184,0.001372745,0.001493615,0.002731562,0.01000907],"category_scores_gemma":[0.004594718,0.001536924,0.001886237,0.0007538857,0.002029563,0.001619138,0.0006548607,0.003468836,0.001896999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00120288,"about_ca_system_score_gemma":0.004430422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008342997,"about_ca_topic_score_gemma":0.002033088,"domain_scores_codex":[0.9969864,0.001746978,0.0002256845,0.0004340272,0.0002471736,0.0003596749],"domain_scores_gemma":[0.9968752,0.0004986186,0.000643777,0.000326979,0.0004111447,0.001244254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.974684,0.01381283,0.001852386,0.0004898668,0.0006252326,0.00005887102,0.0000620375,0.0002862739,0.002191325,0.0001077312,0.0008395271,0.004989839],"study_design_scores_gemma":[0.9458278,0.05107394,0.001770921,0.00001764978,0.0002476402,0.0000280998,0.00001207702,0.0001573646,0.0002015683,0.00007263942,0.0005798841,0.0000103789],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7842832,0.004818628,0.003163233,0.001290022,0.001006499,0.1962769,0.004631999,0.0002199085,0.004309685],"genre_scores_gemma":[0.7667117,0.002532168,0.007250832,0.003161259,0.0008189284,0.2107397,0.004523549,0.00004860523,0.004213222],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01000907,"threshold_uncertainty_score":0.04305619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06576046766288526,"score_gpt":0.4697391174561259,"score_spread":0.4039786497932406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}