{"id":"W2553590829","doi":"10.2196/resprot.6610","title":"A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS)","year":2016,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Peripheral Neuropathies and Disorders","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Eculizumab; Medicine; Guillain-Barre syndrome; Complement system; Immunology; Flaccid paralysis; Clinical trial; Antibody; Internal medicine; Paralysis; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003926963,0.000379372,0.001374759,0.0003385775,0.0002474365,0.0000377494,0.0004335014,0.00008880353,0.0001006229],"category_scores_gemma":[0.003790391,0.0001758969,0.0001875135,0.0006847554,0.0006726225,0.0001462104,0.0003879662,0.0003340343,0.000003459923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839018,"about_ca_system_score_gemma":0.0003893215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062227,"about_ca_topic_score_gemma":0.00008020981,"domain_scores_codex":[0.9939508,0.001732021,0.00118218,0.000763991,0.001639672,0.0007312777],"domain_scores_gemma":[0.9962546,0.00106037,0.0002835713,0.0009196867,0.0011959,0.0002858294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9649414,0.02118005,0.003952143,0.000838049,0.000154929,0.00002436018,0.004087965,0.000002395045,0.0008291268,0.00001956302,0.0002318917,0.003738156],"study_design_scores_gemma":[0.874798,0.1097319,0.01048682,0.002423543,0.00002831052,0.000003293738,0.0005973147,0.00005407678,0.0004073262,0.00003375523,0.001239942,0.0001957015],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.4731749,8.572123e-7,0.000005871151,0.0002054793,0.000005090076,0.5264729,0.00002776689,0.00001499022,0.00009207652],"genre_scores_gemma":[0.4551225,2.139268e-7,0.00005523161,0.00001569167,0.00001875995,0.5446241,0.000002074438,0.00003389982,0.000127505],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.09014339,"threshold_uncertainty_score":0.7172869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06576046766288526,"score_gpt":0.4697391174561259,"score_spread":0.4039786497932406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}