{"id":"W2553625841","doi":"10.1371/journal.ppat.1005976","title":"Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Malaria Research and Control","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canada Foundation for Innovation; NIH Office of the Director; Alberta Innovates; National Research Foundation; Alberta Innovates - Health Solutions; Burroughs Wellcome Fund","keywords":"Biology; Plasmodium falciparum; Drug resistance; Mutant; Allele; Chloroquine; Genetics; Virology; Gene; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008071693,0.0001854852,0.0001594784,0.0001386253,0.0001101541,0.0001708728,0.0001721093,0.0001718874,0.000595696],"category_scores_gemma":[0.0001385233,0.00008452346,0.0001554523,0.0001460484,0.000152032,0.0000827676,0.0001654132,0.0003778824,0.0001506569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002745282,"about_ca_system_score_gemma":0.0001934565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002610388,"about_ca_topic_score_gemma":0.004163272,"domain_scores_codex":[0.9999059,0.00001273286,0.000009718366,0.00002269375,0.00003172711,0.00001712207],"domain_scores_gemma":[0.9999093,0.00001492257,0.00003556209,0.00001291332,0.000009427159,0.00001791392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002384425,0.000008605644,0.0004445325,0.000007891646,0.000002598188,0.00007250312,0.00001327183,0.0000414584,0.9987233,0.0000464963,0.000009782556,0.0006057775],"study_design_scores_gemma":[0.00001460874,0.0003774108,0.04128668,0.000007223694,0.00002404178,0.001650412,0.0001086379,0.002746952,0.9518167,0.00009211598,0.001861137,0.00001410562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985818,0.00006582319,0.0007791853,0.00002175912,0.000002859286,0.000006825029,0.0001547902,0.00002034744,0.0003666704],"genre_scores_gemma":[0.9971692,0.0001128163,0.001532351,0.00002427807,0.000002099324,0.000008586806,0.0003032857,0.00002217585,0.0008252024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002610388,"threshold_uncertainty_score":0.005190372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01968212883330674,"score_gpt":0.2700784944798313,"score_spread":0.2503963656465246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}