{"id":"W2553625841","doi":"10.1371/journal.ppat.1005976","title":"Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Malaria Research and Control","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canada Foundation for Innovation; NIH Office of the Director; Alberta Innovates; National Research Foundation; Alberta Innovates - Health Solutions; Burroughs Wellcome Fund","keywords":"Biology; Plasmodium falciparum; Drug resistance; Mutant; Allele; Chloroquine; Genetics; Virology; Gene; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987622,0.0002523689,0.0007344675,0.0001245696,0.00009265612,0.00001265794,0.0001545181,0.0001123806,0.0001082937],"category_scores_gemma":[0.0002081376,0.0001769656,0.0001123287,0.0001517653,0.000240141,0.0001222052,0.0000879512,0.0001851185,0.00001830975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009560125,"about_ca_system_score_gemma":0.0001359658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000659089,"about_ca_topic_score_gemma":0.0000491283,"domain_scores_codex":[0.9979843,0.000170078,0.0004041477,0.0005104782,0.000320568,0.0006104257],"domain_scores_gemma":[0.9986195,0.0001648962,0.0001826886,0.0004269705,0.0003154121,0.0002905351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001431384,0.0002413376,0.007826857,0.0001168506,0.0002175749,0.00001919276,0.0003269002,7.409599e-7,0.9875623,0.0009451354,0.0006471701,0.0006645794],"study_design_scores_gemma":[0.007670013,0.0001922476,0.6089711,0.0003747404,0.0003817636,0.00001836122,0.000133823,0.000842699,0.3783655,0.00073515,0.001971227,0.0003433072],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924807,0.00184203,0.0005590007,0.002907559,0.00008203782,0.0009048426,0.0009726972,0.00005148591,0.0001996378],"genre_scores_gemma":[0.9977434,0.0003033922,0.0001669805,0.0001487323,0.0001972945,0.0001284748,0.00004162738,0.00002968089,0.001240433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6091967,"threshold_uncertainty_score":0.7216449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01968212883330674,"score_gpt":0.2700784944798313,"score_spread":0.2503963656465246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}