{"id":"W2553766880","doi":"10.1182/blood.v124.21.4464.4464","title":"Mature Results of a Phase 1-2 Open-Label, Dose-Escalation Study of Intravenous SNS01-T in Patients (pts) with Relapsed or Refractory B-Cell Malignancies","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Gastroenterology; Aldesleukin; Multiple myeloma; Oncology; Immunology; Adverse effect; Cytokine; Interleukin 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001412881,0.00109258,0.001624522,0.0003696744,0.0003168139,0.0006324307,0.0004815136,0.0007884132,0.00303047],"category_scores_gemma":[0.0007112005,0.0003283143,0.0009452151,0.0003025528,0.0006610174,0.0006238397,0.0002390601,0.001714287,0.0007003526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006223367,"about_ca_system_score_gemma":0.0009461386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005356983,"about_ca_topic_score_gemma":0.001610065,"domain_scores_codex":[0.9995627,0.0002149875,0.00002669467,0.00006968455,0.00005214176,0.00007375007],"domain_scores_gemma":[0.9994295,0.000100974,0.0001007196,0.00005584151,0.00005449538,0.0002584867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5335904,0.1181256,0.01315471,0.0008616106,0.001262513,0.0003182683,0.0004881228,0.005801884,0.1883972,0.0003180234,0.004591722,0.13309],"study_design_scores_gemma":[0.1172342,0.8431957,0.0201611,0.0000311422,0.0005222373,0.0002754746,0.0001055571,0.001428779,0.01286067,0.0002359268,0.003919345,0.00002979024],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943132,0.0006734814,0.0007704801,0.0001439673,0.00005145212,0.001687265,0.00104163,0.00005549449,0.001263081],"genre_scores_gemma":[0.9885776,0.0007051383,0.00239501,0.000345025,0.00008488011,0.002157568,0.002945295,0.00004059931,0.002748951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00303047,"threshold_uncertainty_score":0.01013798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249713509400291,"score_gpt":0.263139015978046,"score_spread":0.250641880884043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}