{"id":"W2553766880","doi":"10.1182/blood.v124.21.4464.4464","title":"Mature Results of a Phase 1-2 Open-Label, Dose-Escalation Study of Intravenous SNS01-T in Patients (pts) with Relapsed or Refractory B-Cell Malignancies","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Gastroenterology; Aldesleukin; Multiple myeloma; Oncology; Immunology; Adverse effect; Cytokine; Interleukin 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632778,0.0001129902,0.0002054045,0.00004696242,0.00002754896,0.000008642579,0.0002345453,0.00008688756,0.000002076419],"category_scores_gemma":[0.00006579034,0.00008506486,0.00001255197,0.0001593138,0.00003757525,0.00000668766,0.00008902101,0.00006553393,0.000001149852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002857085,"about_ca_system_score_gemma":0.00004608951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006997212,"about_ca_topic_score_gemma":0.0001160058,"domain_scores_codex":[0.9990978,0.0000748836,0.0003245858,0.0002569835,0.0001209307,0.0001248291],"domain_scores_gemma":[0.9991671,0.00001503405,0.0002525058,0.0004304534,0.00009803593,0.00003683376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004068488,0.05385019,0.005646173,0.00007021824,0.00007860553,0.000002066701,0.0009052967,0.00001629561,0.9287987,0.00003430703,0.0004080514,0.006121611],"study_design_scores_gemma":[0.1711583,0.0261423,0.09113536,0.00009615925,0.0002791907,0.000003145762,0.0005224555,0.00002897539,0.7037064,0.00002984805,0.006435286,0.0004625976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986137,0.0000781596,0.00004453273,0.00001136816,0.00001913578,0.0005975394,0.0001284544,0.000003939105,0.0005031319],"genre_scores_gemma":[0.9989122,0.00002407091,0.0005288091,0.00002156563,0.00002699002,0.00004389569,0.0002401111,0.00001208683,0.000190329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2250924,"threshold_uncertainty_score":0.3468844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249713509400291,"score_gpt":0.263139015978046,"score_spread":0.250641880884043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}