{"id":"W2553822584","doi":"10.1016/j.antiviral.2016.11.007","title":"The I427T neuraminidase (NA) substitution, located outside the NA active site of an influenza A(H1N1)pdm09 variant with reduced susceptibility to NA inhibitors, alters NA properties and impairs viral fitness","year":2016,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Zanamivir; Neuraminidase; Oseltamivir; Titer; Virology; Recombinant DNA; Influenza A virus; Virus; Biology; Mutant; Viral replication; Enzyme; Neuraminidase inhibitor; Chemistry; Molecular biology; Gene; Biochemistry; Coronavirus disease 2019 (COVID-19); Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004025261,0.001039543,0.0006667052,0.0003231092,0.0006050752,0.0004521932,0.0006202044,0.001160165,0.003296905],"category_scores_gemma":[0.0005530132,0.000268638,0.0009374642,0.0004170109,0.0008119766,0.0002874684,0.000462889,0.0009587114,0.00107232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004862651,"about_ca_system_score_gemma":0.0005801559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003284566,"about_ca_topic_score_gemma":0.003124317,"domain_scores_codex":[0.9995008,0.0001576343,0.00007321127,0.00008677213,0.0001131967,0.00006845556],"domain_scores_gemma":[0.9996711,0.0000598488,0.00008350691,0.00003276127,0.00004321153,0.0001094955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002649287,0.0004157003,0.004722041,0.0001133543,0.000258591,0.004049667,0.0001737731,0.0007217526,0.9745632,0.001309938,0.0007969455,0.01022573],"study_design_scores_gemma":[0.001699542,0.007556069,0.04398673,0.000160148,0.0007493935,0.02259854,0.0007440537,0.009267121,0.8894333,0.001056875,0.02254117,0.0002070897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930286,0.0003445639,0.00248859,0.0003006879,0.0002767658,0.0000905926,0.0007261944,0.00006712748,0.002676851],"genre_scores_gemma":[0.9946854,0.000181708,0.002517947,0.0002782524,0.0000504483,0.00004840405,0.0007235895,0.00006503285,0.001449255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003296905,"threshold_uncertainty_score":0.01102924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1068078444184873,"score_gpt":0.386721984593594,"score_spread":0.2799141401751067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}