{"id":"W2553822584","doi":"10.1016/j.antiviral.2016.11.007","title":"The I427T neuraminidase (NA) substitution, located outside the NA active site of an influenza A(H1N1)pdm09 variant with reduced susceptibility to NA inhibitors, alters NA properties and impairs viral fitness","year":2016,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Zanamivir; Neuraminidase; Oseltamivir; Titer; Virology; Recombinant DNA; Influenza A virus; Virus; Biology; Mutant; Viral replication; Enzyme; Neuraminidase inhibitor; Chemistry; Molecular biology; Gene; Biochemistry; Coronavirus disease 2019 (COVID-19); Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":["sts"],"category_scores_codex":[0.004131534,0.0004088427,0.0005806366,0.0003546529,0.001330796,0.0001825193,0.0005280035,0.0001522919,0.00000837438],"category_scores_gemma":[0.005076197,0.0001746326,0.0001057117,0.001143875,0.004952941,0.0007281238,0.0007052339,0.0009286788,0.00005116161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003628057,"about_ca_system_score_gemma":0.001016472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002392408,"about_ca_topic_score_gemma":0.0006617843,"domain_scores_codex":[0.9935927,0.001473731,0.0006177286,0.0008786315,0.002053887,0.001383308],"domain_scores_gemma":[0.9948609,0.001180968,0.0001498556,0.001271058,0.002214624,0.0003225692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01772043,0.0003928651,0.03429388,0.0002529737,0.0003819425,0.0001742866,0.006500586,0.000008487334,0.9007946,0.0003119305,0.0005103202,0.03865768],"study_design_scores_gemma":[0.003620969,0.005091816,0.3142131,0.0008535186,0.0000725307,0.00004377493,0.004338242,0.0004149001,0.6701249,0.00009342079,0.0007219137,0.0004109669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926354,0.0003983317,0.00002488173,0.003828906,0.00007547159,0.002697416,0.00008084906,0.00007019055,0.000188591],"genre_scores_gemma":[0.9987631,0.0001557084,0.0000419065,0.0002387306,0.0001392166,0.0002272455,0.000007856894,0.0000517204,0.0003744886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2799192,"threshold_uncertainty_score":0.9999694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1068078444184873,"score_gpt":0.386721984593594,"score_spread":0.2799141401751067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}