{"id":"W2553890461","doi":"10.1038/srep37021","title":"HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; University of Pittsburgh","keywords":"Endosome; Endocytosis; Cell biology; MHC class I; Bimolecular fluorescence complementation; Major histocompatibility complex; Endocytic cycle; Biology; Golgi apparatus; Intracellular; Cell; Immune system; Immunology; Genetics; Endoplasmic reticulum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723652,0.0003633421,0.0002849012,0.0001967071,0.0001810205,0.0004557048,0.0003612805,0.0002835277,0.001012694],"category_scores_gemma":[0.0001210615,0.0001096039,0.0001087245,0.0001125026,0.00026872,0.0002583264,0.0002159177,0.0005324269,0.0004363204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004809033,"about_ca_system_score_gemma":0.0003219594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001168493,"about_ca_topic_score_gemma":0.001238916,"domain_scores_codex":[0.9998695,0.00002184439,0.000006772758,0.0000264768,0.00004324897,0.00003213065],"domain_scores_gemma":[0.9999553,0.000008320614,0.00001040408,0.00000727828,0.000008401083,0.0000103712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002168674,0.000009674607,0.0000742452,0.00002056997,0.000001468641,0.00003105037,0.000005661103,0.00004026771,0.9977788,0.0004611278,0.00004206804,0.001513427],"study_design_scores_gemma":[0.000002678586,0.00002183108,0.0006166029,0.000003180584,0.000002323889,0.0001357505,0.000009046378,0.0008150045,0.9948196,0.00007305409,0.003498949,0.000001955915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600469,0.005167499,0.02722491,0.0003452344,0.00004465765,0.00004404167,0.0003165954,0.0002569208,0.006553191],"genre_scores_gemma":[0.9753439,0.002259504,0.01228694,0.00007891767,0.00001317894,0.00003679678,0.0003673754,0.00004223429,0.009571144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168493,"threshold_uncertainty_score":0.003489256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153201245447832,"score_gpt":0.2399573681716533,"score_spread":0.228425355717175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}