{"id":"W2553977523","doi":"10.1093/mmy/myw118","title":"Successful treatment of<i>Aspergillus</i>ventriculitis through voriconazole adaptive pharmacotherapy, immunomodulation, and therapeutic monitoring of cerebrospinal fluid (1→3)-β-D-glucan","year":2016,"lang":"en","type":"review","venue":"Medical Mycology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sick Kids Foundation","keywords":"Ventriculitis; Voriconazole; Aspergillosis; Medicine; Pharmacotherapy; Aspergillus; Germinoma; Meningoencephalitis; Cerebrospinal fluid; Therapeutic drug monitoring; Meningitis; Immunology; Internal medicine; Pharmacology; Biology; Surgery; Drug; Microbiology; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002834042,0.0004680218,0.00281959,0.0001402458,0.00007362435,0.000004472739,0.0001985512,0.0005731871,0.001544793],"category_scores_gemma":[0.0001414623,0.0002852088,0.0005229076,0.0002964771,0.0006707118,0.00005123302,0.00005247524,0.0002456594,0.00001469135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003499764,"about_ca_system_score_gemma":0.001051113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001567173,"about_ca_topic_score_gemma":0.00001085216,"domain_scores_codex":[0.996902,0.0003610583,0.001175439,0.0005701488,0.0005623364,0.0004289929],"domain_scores_gemma":[0.9977772,0.0008405123,0.0005314791,0.0004109448,0.0002104512,0.0002293816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004135517,0.0006359456,0.01318724,0.004500865,0.001184947,0.00008098323,0.0001863415,5.344356e-8,0.0002275235,0.0004766977,0.00004230487,0.9790636],"study_design_scores_gemma":[0.005530474,0.005612898,0.02113026,0.01497458,0.002739008,0.0003228911,0.0001727061,0.000007678694,0.0007624611,0.0003261717,0.9478654,0.0005554754],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01552808,0.9820566,0.0003301667,0.0001168372,0.0005603218,0.001012126,0.00008702467,0.00002663526,0.0002822316],"genre_scores_gemma":[0.09082002,0.9080477,0.0001791621,0.00003541317,0.0004846088,0.00009747999,0.00002941386,0.00004092051,0.0002652801],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9785081,"threshold_uncertainty_score":0.99996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05153529980488843,"score_gpt":0.3800728267645782,"score_spread":0.3285375269596898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}