{"id":"W2553977523","doi":"10.1093/mmy/myw118","title":"Successful treatment of<i>Aspergillus</i>ventriculitis through voriconazole adaptive pharmacotherapy, immunomodulation, and therapeutic monitoring of cerebrospinal fluid (1→3)-β-D-glucan","year":2016,"lang":"en","type":"review","venue":"Medical Mycology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sick Kids Foundation","keywords":"Ventriculitis; Voriconazole; Aspergillosis; Medicine; Pharmacotherapy; Aspergillus; Germinoma; Meningoencephalitis; Cerebrospinal fluid; Therapeutic drug monitoring; Meningitis; Immunology; Internal medicine; Pharmacology; Biology; Surgery; Drug; Microbiology; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003210975,0.0004910181,0.0008091924,0.001443735,0.0002023277,0.0005528547,0.0005665908,0.0006439491,0.0008885899],"category_scores_gemma":[0.0004279022,0.0001306093,0.0004342828,0.0007873166,0.0002980036,0.0005898308,0.0003654902,0.000925399,0.0005776605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296542,"about_ca_system_score_gemma":0.0006787828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000417798,"about_ca_topic_score_gemma":0.0009344207,"domain_scores_codex":[0.9998614,0.00002686418,0.00002985813,0.00002075729,0.00004504768,0.00001600606],"domain_scores_gemma":[0.9998504,0.00005970668,0.0000369339,0.00000606613,0.00003036446,0.00001642131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.00008449087,0.00009811568,0.0006862793,0.01151831,0.0001291426,0.001947102,0.00006336878,0.0002078706,0.004025642,0.001201534,0.007338783,0.9726993],"study_design_scores_gemma":[0.00007560567,0.0005123389,0.008327395,0.007585104,0.0004427817,0.04676558,0.0002179568,0.0002886093,0.006049094,0.002057387,0.9276248,0.00005341021],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0009607185,0.9976636,0.0001558748,0.0001834373,0.00008883511,0.000005052217,0.000008837977,0.000006492832,0.0009272594],"genre_scores_gemma":[0.007018644,0.9918079,0.0004015488,0.0002021856,0.0001617025,0.000007501805,0.00003079103,0.000002102181,0.0003676164],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001443735,"threshold_uncertainty_score":0.002972603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05153529980488843,"score_gpt":0.3800728267645782,"score_spread":0.3285375269596898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}