{"id":"W2554041296","doi":"10.1182/blood.v112.11.261.261","title":"PROPEL: A Multi-Center Phase 2 Open-Label Study of Pralatrexate (PDX) with Vitamin B12 and Folic Acid Supplementation in Patients with Replapsed or Refractory Peripheral T-Cell Lymphoma","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Interim analysis; Clinical endpoint; Internal medicine; Phases of clinical research; Antifolate; Oncology; Refractory (planetary science); Clinical trial; Neutropenia; Peripheral T-cell lymphoma; Gastroenterology; Cancer; Surgery; Pharmacology; Chemotherapy; Immunology; Antimetabolite; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002096934,0.001753027,0.002164318,0.0007003396,0.0004836817,0.001142833,0.001250041,0.001430347,0.003717247],"category_scores_gemma":[0.001017676,0.0007771734,0.001174855,0.000527544,0.001087071,0.001456856,0.0005943374,0.002881973,0.0008825593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000994108,"about_ca_system_score_gemma":0.001843428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006905606,"about_ca_topic_score_gemma":0.001525237,"domain_scores_codex":[0.9994853,0.0002610576,0.00003062625,0.00007271151,0.00005083072,0.00009950047],"domain_scores_gemma":[0.9991633,0.0001372368,0.0001458526,0.00007348505,0.00006213987,0.000417995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8219936,0.06919165,0.003691218,0.0008655085,0.0009111147,0.0003378936,0.0003009693,0.001589844,0.036287,0.0001947544,0.001750302,0.06288618],"study_design_scores_gemma":[0.660552,0.3327537,0.003013102,0.0000153911,0.0002234696,0.0001430033,0.00003365818,0.0005564097,0.00170029,0.00007351769,0.0009181907,0.00001731356],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932958,0.001234893,0.0005407659,0.0003293453,0.00007394962,0.00290335,0.0006638762,0.0001048363,0.0008531366],"genre_scores_gemma":[0.987688,0.001041109,0.002425376,0.0006497928,0.0002249585,0.004319574,0.001480572,0.00003419216,0.002136364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003717247,"threshold_uncertainty_score":0.01243544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122741258708996,"score_gpt":0.2955724908423342,"score_spread":0.2643450782552442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}