{"id":"W2554256100","doi":"10.1016/j.bbamem.2016.11.006","title":"Functional characterization of two prokaryotic pentameric ligand-gated ion channel chimeras – role of the GLIC transmembrane domain in proton sensing","year":2016,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Ligand-gated ion channel; Ion channel; Transmembrane domain; Biophysics; Agonist; Gating; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002643475,0.0003777442,0.0004638194,0.0001839318,0.00008292819,0.00001631158,0.0003575502,0.0001890225,0.00001282005],"category_scores_gemma":[0.00003975332,0.0002501541,0.0002576033,0.0006946619,0.0003722267,0.00002888377,0.0001565549,0.0001293184,0.00000583867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003035613,"about_ca_system_score_gemma":0.0001581687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006322652,"about_ca_topic_score_gemma":0.00001985354,"domain_scores_codex":[0.9977065,0.0002778054,0.0006690699,0.0006138358,0.0003546527,0.0003781711],"domain_scores_gemma":[0.9986476,0.00003622878,0.000549071,0.0005573641,0.0001362752,0.0000735042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004536682,0.0004515779,0.0001254147,0.0001231907,0.0001173636,1.735347e-7,0.0002721161,0.000003105335,0.9977148,0.00001465259,0.000008088919,0.0007158393],"study_design_scores_gemma":[0.002142741,0.0002910807,0.01381685,0.0002128224,0.0000501096,0.00001343391,0.00007909098,0.00005882193,0.9828432,0.0000523786,0.0001291277,0.000310316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967034,0.00005851727,0.00008025502,0.001324728,0.0002488959,0.001398012,0.0001214083,0.00002595861,0.00003876736],"genre_scores_gemma":[0.9989548,0.0002216158,0.00006682987,0.00008158702,0.0002512775,0.00004217487,0.0002458673,0.00005943727,0.00007641054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01487158,"threshold_uncertainty_score":0.9999951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007519078186554264,"score_gpt":0.2284639861408845,"score_spread":0.2209449079543302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}