{"id":"W2554333293","doi":"10.1182/blood.v118.21.1556.1556","title":"Selective Small Molecule Inhibition of P110α and δ Isoforms of PI3 Kinase Is Cytotoxic to Human AML Progenitors","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"IC50; Kinase; Myeloid leukemia; Progenitor cell; Molecular biology; Protein kinase B; Gene isoform; Chemistry; Biology; Stem cell; Cancer research; Biochemistry; In vitro; Signal transduction; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232435,0.0003019241,0.0002591343,0.0001837769,0.0001118712,0.0002930617,0.0001722694,0.0001361017,0.001621097],"category_scores_gemma":[0.0001143161,0.0001331856,0.000185476,0.0002063975,0.0001036612,0.00008383903,0.0001823548,0.0004920679,0.0004936669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001751203,"about_ca_system_score_gemma":0.0002320441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004794752,"about_ca_topic_score_gemma":0.0006556198,"domain_scores_codex":[0.999934,0.000007330767,0.000006885121,0.00001102584,0.00001900591,0.00002179723],"domain_scores_gemma":[0.9999505,0.00001279115,0.000006624826,0.000007457448,0.000004641063,0.00001785244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001459357,0.0003938627,0.0006086934,0.0001313486,0.00003135313,0.0001349035,0.00005998995,0.0006577347,0.9750546,0.0002316069,0.0005134455,0.02072316],"study_design_scores_gemma":[0.0006186499,0.007889981,0.0091906,0.0000346126,0.00007933404,0.0008502025,0.00005947894,0.002203896,0.9686843,0.0001546483,0.01022325,0.00001117356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927689,0.002854305,0.0008691941,0.00006572058,0.00003425878,0.00007698081,0.0003662562,0.00007341149,0.002891076],"genre_scores_gemma":[0.9932089,0.002358067,0.0006720358,0.00005593746,0.00001454381,0.00005783454,0.00110041,0.0000118796,0.002520353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001621097,"threshold_uncertainty_score":0.005423129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02857760411720545,"score_gpt":0.274772089117794,"score_spread":0.2461944850005886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}