{"id":"W2554338514","doi":"10.7717/peerj.2445","title":"Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells","year":2016,"lang":"en","type":"article","venue":"PeerJ","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University Health Centre; Institut National de la Recherche Scientifique","funders":"","keywords":"Autophagy; Unfolded protein response; ATG5; Endoplasmic reticulum; Lithocholic acid; Biology; LNCaP; Cancer cell; Cell biology; Cancer research; Apoptosis; Chemistry; Endocrinology; Biochemistry; Cancer; Bile acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008826445,0.0002577581,0.0003104231,0.0002587682,0.000218588,0.0002267546,0.0001125007,0.0001831585,0.001207915],"category_scores_gemma":[0.00007131054,0.00014294,0.0003507115,0.0004794325,0.000124517,0.00009165826,0.0001823308,0.0004982884,0.0002617956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455176,"about_ca_system_score_gemma":0.0003618585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003673964,"about_ca_topic_score_gemma":0.005448649,"domain_scores_codex":[0.999871,0.00001748541,0.00001246454,0.00002013349,0.00004521675,0.00003365592],"domain_scores_gemma":[0.9999501,0.00000591639,0.00001044318,0.000006737625,0.00001416254,0.00001257925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004736854,0.0001027699,0.0006856458,0.0001262178,0.00002383788,0.0002343582,0.00005665523,0.00005909393,0.9962127,0.00004795253,0.0001480889,0.00182892],"study_design_scores_gemma":[0.00005479737,0.001903272,0.02610458,0.00001231045,0.00007322189,0.0009497945,0.0001534436,0.0005843381,0.9662702,0.00005469823,0.003828194,0.00001117822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921718,0.004663676,0.0007867931,0.0001209475,0.00004385026,0.00004135095,0.0006090722,0.000087138,0.001475334],"genre_scores_gemma":[0.9930766,0.00252403,0.0005418059,0.0001011319,0.000009507678,0.00004660211,0.00106739,0.000008698316,0.002624284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003673964,"threshold_uncertainty_score":0.007305145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006123556057762233,"score_gpt":0.2433962548321938,"score_spread":0.2372726987744316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}