{"id":"W2554470664","doi":"10.1021/acs.jpcb.6b09620","title":"Hydrolytic Glycosidic Bond Cleavage in RNA Nucleosides: Effects of the 2′-Hydroxy Group and Acid–Base Catalysis","year":2016,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation; University of Lethbridge","keywords":"Chemistry; Nucleobase; Glycosidic bond; Nucleophile; Leaving group; Catalysis; Bond cleavage; Deprotonation; RNA; Nucleic acid; Stereochemistry; Hydrogen bond; Hydrolysis; Acid catalysis; DNA; Molecule; Organic chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796542,0.0004971903,0.000343159,0.0001079979,0.0001514222,0.0002913964,0.0003183177,0.000278738,0.002312147],"category_scores_gemma":[0.0003569291,0.0002089219,0.000244014,0.0001196497,0.0002444896,0.0003222942,0.0002491477,0.0005855265,0.0002332757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002068064,"about_ca_system_score_gemma":0.0002336559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001439027,"about_ca_topic_score_gemma":0.001738467,"domain_scores_codex":[0.999894,0.00001192443,0.000004871111,0.00001987145,0.00002880535,0.00004042603],"domain_scores_gemma":[0.9998496,0.00008455318,0.00002269416,0.00000760975,0.00001608434,0.00001950635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008468614,0.0001718318,0.001408168,0.0005833902,0.00006491219,0.0004662462,0.0001528963,0.01503222,0.9710218,0.001563254,0.0002319661,0.008456363],"study_design_scores_gemma":[0.00006846507,0.001380747,0.005583073,0.00003879357,0.00006004747,0.0001648927,0.0001806324,0.06925936,0.9207838,0.0006042892,0.001827381,0.00004854452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954306,0.001053197,0.0009017677,0.00004415595,0.00002392307,0.00001262457,0.00005648278,0.00002394252,0.002453258],"genre_scores_gemma":[0.9985232,0.0006153532,0.000440195,0.00001976447,0.000004084381,0.000007832949,0.00005859331,0.000009754847,0.000321413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002312147,"threshold_uncertainty_score":0.007734895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002476786720997583,"score_gpt":0.1936948187504884,"score_spread":0.1912180320294908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}