{"id":"W2554549910","doi":"10.1124/dmd.116.073833","title":"Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase","year":2016,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; American Society for Pharmacology and Experimental Therapeutics","keywords":"Pregnane X receptor; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor; Glucocorticoid receptor; Nuclear receptor; Glucocorticoid; Constitutive androstane receptor; Internal medicine; Endocrinology; Cytochrome P450; Biology; Pregnane; Enzyme inducer; Receptor; Chemistry; Biochemistry; Transcription factor; Enzyme; Medicine; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000271507,0.0005721312,0.000385252,0.0005125835,0.000409021,0.0004322619,0.0002803636,0.0004001319,0.003100541],"category_scores_gemma":[0.0003824503,0.0004042369,0.0005470831,0.0002883314,0.0005707761,0.0006009692,0.0003719366,0.0005402601,0.0006039618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006826886,"about_ca_system_score_gemma":0.0006086366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003379117,"about_ca_topic_score_gemma":0.007571102,"domain_scores_codex":[0.9997268,0.00006436931,0.00002192881,0.00004356716,0.0000487147,0.00009454162],"domain_scores_gemma":[0.9994907,0.0001232437,0.00008819742,0.00008886262,0.0000617011,0.0001472631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003905515,0.000119269,0.002411866,0.00009815775,0.00003096646,0.0005561782,0.0001725279,0.00009783002,0.9860212,0.001170366,0.00007826207,0.005337886],"study_design_scores_gemma":[0.0001239692,0.0009100414,0.04920315,0.00002321271,0.0001045373,0.0007712753,0.0003385985,0.0004308017,0.9449282,0.0003765551,0.002765008,0.00002454432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830101,0.009898433,0.002512365,0.0004016052,0.00009399126,0.00004188895,0.0007298073,0.0001140971,0.00319779],"genre_scores_gemma":[0.9900545,0.001886336,0.000823391,0.0000518491,0.00002019972,0.00002816584,0.0004941814,0.00001987324,0.006621537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003379117,"threshold_uncertainty_score":0.01037234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002458657698199034,"score_gpt":0.1899849498032678,"score_spread":0.1875262921050688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}