{"id":"W2554549910","doi":"10.1124/dmd.116.073833","title":"Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase","year":2016,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; American Society for Pharmacology and Experimental Therapeutics","keywords":"Pregnane X receptor; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor; Glucocorticoid receptor; Nuclear receptor; Glucocorticoid; Constitutive androstane receptor; Internal medicine; Endocrinology; Cytochrome P450; Biology; Pregnane; Enzyme inducer; Receptor; Chemistry; Biochemistry; Transcription factor; Enzyme; Medicine; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002091865,0.0002036837,0.0003476015,0.0001173843,0.00004231058,0.00001143269,0.00006069219,0.0002191704,0.00001441],"category_scores_gemma":[0.00004418534,0.000158214,0.00005587342,0.0001366735,0.0002166163,0.000035848,0.00004354485,0.00009383429,0.000002280648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001078154,"about_ca_system_score_gemma":0.00003108703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007722028,"about_ca_topic_score_gemma":0.000005802862,"domain_scores_codex":[0.9988096,0.0001327982,0.0003426689,0.0003895111,0.0001292276,0.0001961322],"domain_scores_gemma":[0.9994432,0.00002962987,0.0001695357,0.0001928971,0.00004426084,0.0001205012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006675276,0.000127995,0.0005923415,0.0001205807,0.00005233424,4.306869e-7,0.0004202256,0.000001928777,0.9811379,0.0001671618,0.00003944873,0.01667217],"study_design_scores_gemma":[0.002080826,0.000319816,0.01054427,0.0002521215,0.0001034559,0.00001535032,0.000275621,0.00004435663,0.9854396,0.0001025729,0.0005955682,0.0002264266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819896,0.01720863,0.00002113839,0.0001388151,0.0001135099,0.000436786,0.00006188497,0.00000952067,0.00002012633],"genre_scores_gemma":[0.9909283,0.008321422,0.0004516242,0.00001857287,0.00007674983,0.00002452022,0.0001185724,0.00002822878,0.00003199522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01644574,"threshold_uncertainty_score":0.645178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002458657698199034,"score_gpt":0.1899849498032678,"score_spread":0.1875262921050688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}