{"id":"W2554550600","doi":"10.7554/elife.20143","title":"A Dynamic molecular basis for malfunction in disease mutants of p97/VCP","year":2016,"lang":"en","type":"article","venue":"eLife","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Molecular Biology Organization","keywords":"Allosteric regulation; Signal transducing adaptor protein; AAA proteins; Cell biology; Mutation; Biology; Function (biology); Mutant; Point mutation; ATPase; Computational biology; Enzyme; Biochemistry; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008436124,0.00009544784,0.0001140713,0.0000393418,0.00001508243,0.000004074422,0.00008246985,0.00005536953,0.00002332153],"category_scores_gemma":[0.0005174445,0.00007092761,0.0001097568,0.00004536437,0.00004236562,0.000002899198,0.00003612606,0.00001644664,0.000004470535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001391376,"about_ca_system_score_gemma":0.00007071662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000661976,"about_ca_topic_score_gemma":0.00001405761,"domain_scores_codex":[0.9992322,0.00002284752,0.0002446469,0.0002349111,0.0001034135,0.000161967],"domain_scores_gemma":[0.9994579,0.00001510955,0.0001153073,0.0002410114,0.00005876014,0.0001118864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006583533,0.0001405504,0.02970051,0.00007331106,0.00003122418,0.00001330532,0.0000104287,0.00006884327,0.9641009,0.0001959933,0.0003573618,0.004649254],"study_design_scores_gemma":[0.005034605,0.000476714,0.162787,0.0003051653,0.0001065984,0.000004449344,0.000069369,0.001043715,0.8201591,0.0006021064,0.008858941,0.0005522377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909055,0.0005959676,0.007676171,0.0002173274,0.00008513175,0.0001954333,0.0001911815,0.000005817415,0.0001274309],"genre_scores_gemma":[0.9989752,0.0001815487,0.000345032,0.000137418,0.00002600849,0.0000694457,0.00004424066,0.00001538942,0.0002057742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1439417,"threshold_uncertainty_score":0.2892344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004719955263214628,"score_gpt":0.2441193084215668,"score_spread":0.2393993531583522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}