{"id":"W2554565295","doi":"10.1007/s00216-016-0076-x","title":"Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry","year":2016,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Angiochem (Canada); Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mass spectrometry imaging; Mass spectrometry; Immunohistochemistry; Mucopolysaccharidosis; Pathology; Chemistry; Chromatography; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381315,0.0003387833,0.0001405287,0.0004680563,0.0001924397,0.0001920187,0.0001976454,0.0002409988,0.0006938743],"category_scores_gemma":[0.00007744625,0.0001612649,0.0001600301,0.0001620988,0.0001995049,0.00034338,0.0002005241,0.000423125,0.0001665953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001836409,"about_ca_system_score_gemma":0.0001549708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008539342,"about_ca_topic_score_gemma":0.001000938,"domain_scores_codex":[0.9999454,0.00000388414,0.000003844948,0.00001797758,0.00001269515,0.0000161328],"domain_scores_gemma":[0.9999322,0.000006454516,0.00002510986,0.000004161368,0.00001634339,0.00001572504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000385857,0.000003314808,0.0001512704,0.0000099751,0.000002618885,0.00002709419,0.0000101057,0.00001146079,0.9992931,0.00004787874,0.00001362803,0.0003909428],"study_design_scores_gemma":[0.000005890103,0.0000645528,0.01114676,0.00000511145,0.00002940718,0.0006002462,0.00006941611,0.00101016,0.9862381,0.0001406348,0.0006812866,0.000008433885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887139,0.0008892125,0.00892052,0.00009603737,0.00001527075,0.00001016165,0.0003325574,0.00007619428,0.0009460483],"genre_scores_gemma":[0.9798871,0.001378922,0.01448681,0.0001229655,0.00001725807,0.00005761974,0.00048382,0.00007475018,0.003490662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008539342,"threshold_uncertainty_score":0.002321303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007016060545533088,"score_gpt":0.2507022770279752,"score_spread":0.2436862164824421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}