{"id":"W2554832534","doi":"10.1001/jama.2016.16951","title":"Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients","year":2016,"lang":"en","type":"article","venue":"JAMA","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1154,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Libin Cardiovascular Institute of Alberta","funders":"","keywords":"Medicine; Evolocumab; Alirocumab; Statin; Internal medicine; Placebo; PCSK9; Tolerability; Cardiology; Coronary atherosclerosis; Coronary artery disease; Atheroma; Intravascular ultrasound; Urology; Gastroenterology; Cholesterol; Adverse effect; Lipoprotein; Pathology; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001123345,0.0004191687,0.001041113,0.0001956736,0.0002353738,0.0003985571,0.0002763689,0.0005407368,0.001986356],"category_scores_gemma":[0.002541478,0.0001817668,0.001121909,0.000168542,0.0002278996,0.0003657179,0.0002197729,0.0009149127,0.0002013782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002286557,"about_ca_system_score_gemma":0.0002921893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002515425,"about_ca_topic_score_gemma":0.0006027257,"domain_scores_codex":[0.9995205,0.000230993,0.00005708107,0.00006869825,0.00007082059,0.00005192495],"domain_scores_gemma":[0.9988769,0.0003824575,0.0003378855,0.000070553,0.00006971574,0.0002625067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8070195,0.00533394,0.05616482,0.0008172026,0.002457093,0.0001978106,0.0001097904,0.001065657,0.00645089,0.00009669448,0.0009710419,0.1193156],"study_design_scores_gemma":[0.245425,0.3448168,0.3934309,0.0003262383,0.003273893,0.0006634506,0.000153241,0.003654506,0.004853284,0.000307253,0.003029878,0.0000655694],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960607,0.002776913,0.00006853297,0.00009708633,0.0000569054,0.00008280682,0.0001441447,0.000009018171,0.0007038449],"genre_scores_gemma":[0.9986641,0.0005590923,0.0001207371,0.0001071976,0.00005815519,0.0000718773,0.0001231849,0.000001468154,0.0002941861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001986356,"threshold_uncertainty_score":0.006645024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005424593299470449,"score_gpt":0.2760107170902736,"score_spread":0.2705861237908032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}