{"id":"W2554937526","doi":"10.18632/oncotarget.13636","title":"CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"","keywords":"E2F1; Keratinocyte; Transcription factor; Ubiquitin ligase; Biology; Ubiquitin; Cell biology; Downregulation and upregulation; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004110295,0.0001082286,0.0001114873,0.0001042173,0.00002370555,0.00001647051,0.00009915549,0.0001056762,0.00009978114],"category_scores_gemma":[0.0003108078,0.00008379995,0.00003164223,0.0001124843,0.00001584482,0.000007174843,0.00004942519,0.00003882504,0.00004790516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004075752,"about_ca_system_score_gemma":0.00004739175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002470976,"about_ca_topic_score_gemma":0.0002058963,"domain_scores_codex":[0.9990323,0.0002051275,0.0002077696,0.0002650118,0.00009311522,0.0001966885],"domain_scores_gemma":[0.9996267,0.00004704155,0.00004739552,0.000189896,0.00003374404,0.00005521765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005526394,0.00004260515,0.04482698,0.000004930966,0.000003623042,0.000002189511,0.00008329159,0.0000232366,0.9518722,0.00002961246,0.0005377614,0.002020955],"study_design_scores_gemma":[0.0006649106,0.0002046746,0.1648196,0.0000587977,0.000001403944,0.000001236033,0.00001881693,0.00003252176,0.8273348,0.0003269676,0.006401388,0.0001348794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973872,0.0001715665,0.0007653476,0.001118074,0.0000593807,0.0002385117,0.00002035194,0.000009787431,0.0002298141],"genre_scores_gemma":[0.9971792,0.00004524396,0.0008817944,0.0002073444,0.00007518205,0.0000616117,0.0000605128,0.00001351684,0.001475569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1245373,"threshold_uncertainty_score":0.3417262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278828816896776,"score_gpt":0.2527594298656961,"score_spread":0.2399711416967283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}