{"id":"W2555013871","doi":"10.1371/journal.pone.0165835","title":"SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Research Foundation of Korea; Rural Development Administration; National Research Foundation","keywords":"Gene knockdown; Cancer research; SIRT6; Senescence; DNA damage; Biology; Sirtuin; Gene silencing; Cell culture; Small hairpin RNA; Cell growth; DNA repair; Transfection; Cell cycle; Immortalised cell line; Cell biology; Cell; Gene; DNA; Genetics; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223155,0.0002184315,0.0003603514,0.000275277,0.0001291638,0.0001805045,0.0001435234,0.0001835919,0.001419744],"category_scores_gemma":[0.00008500236,0.0001164023,0.0002646481,0.0001680054,0.0001505657,0.0001495625,0.0001406279,0.0004342963,0.000381399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000140514,"about_ca_system_score_gemma":0.0001230233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002917868,"about_ca_topic_score_gemma":0.0006975346,"domain_scores_codex":[0.9999335,0.00001410485,0.000009410517,0.00001097163,0.00001513765,0.0000168481],"domain_scores_gemma":[0.9999416,0.000007239835,0.00001327957,0.000009650145,0.00000750162,0.00002072493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002670889,0.00004763716,0.0002912086,0.0000581058,0.000009730615,0.00003761477,0.00001700756,0.00004933741,0.9967859,0.00005280446,0.00005910402,0.002324452],"study_design_scores_gemma":[0.00004871703,0.0007924979,0.01034197,0.000005670912,0.00004127563,0.000259967,0.0000367263,0.0008393696,0.9840024,0.00006804943,0.003556407,0.000006917931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930408,0.003287215,0.001842475,0.00009891757,0.00005730137,0.00001689611,0.0002640011,0.0001563022,0.001236084],"genre_scores_gemma":[0.995757,0.001298413,0.0009617509,0.00004647954,0.00001697652,0.00001266812,0.0004416035,0.00001773801,0.001447363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001419744,"threshold_uncertainty_score":0.004749537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02310900861805201,"score_gpt":0.2238900595916037,"score_spread":0.2007810509735517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}