{"id":"W2555159995","doi":"10.1182/blood.v114.22.3879.3879","title":"Preliminary Results of a Phase I Study of the Pan-PI3 Kinase Inhibitor SF1126 in Patients with Relapsed and Refractory Myeloma.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Bortezomib; Cancer research; Medicine; PI3K/AKT/mTOR pathway; Multiple myeloma; Angiogenesis; In vivo; Dexamethasone; Population; Melphalan; PTEN; Paclitaxel; Cancer; Internal medicine; Pharmacology; Oncology; Chemistry; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001060753,0.001301562,0.002358358,0.0003214163,0.0004219561,0.0006065872,0.0006322698,0.0008780228,0.003444455],"category_scores_gemma":[0.0006260477,0.0003685522,0.001461699,0.000347059,0.0004083848,0.0005802078,0.0002790869,0.001994519,0.001073665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006299372,"about_ca_system_score_gemma":0.0006685816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001395824,"about_ca_topic_score_gemma":0.002839932,"domain_scores_codex":[0.9997228,0.00009617255,0.00001814551,0.00004592332,0.00003654287,0.00008037962],"domain_scores_gemma":[0.9995302,0.0000798541,0.00005753157,0.0000374213,0.00002954881,0.0002654584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3476391,0.05649285,0.01974563,0.001157306,0.002000629,0.002274834,0.0007090358,0.007233575,0.2098027,0.000310837,0.01125185,0.3413817],"study_design_scores_gemma":[0.1928761,0.7031735,0.06569145,0.00006141885,0.001146238,0.002936875,0.000113925,0.002900419,0.02046786,0.000318071,0.01025082,0.00006333086],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814418,0.004859804,0.001875018,0.001175185,0.0001843998,0.00252045,0.002797445,0.0003436947,0.004802185],"genre_scores_gemma":[0.9831603,0.002554754,0.00274002,0.0009014042,0.0001346987,0.001470968,0.005032022,0.00006057189,0.003945357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003444455,"threshold_uncertainty_score":0.01152289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427788272838112,"score_gpt":0.2802882119919745,"score_spread":0.2660103292635934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}