{"id":"W2555197100","doi":"10.1182/blood.v118.21.3266.3266","title":"Comprehensive In Vitro and In Vivo Characterization of Loss and Gain-of-Function Von Willebrand Factor Collagen Binding Variants Using a Mouse Model System,","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Von Willebrand factor; Mutant; Molecular biology; Chemistry; In vivo; Platelet; Missense mutation; Phenotype; In vitro; Von Willebrand disease; Recombinant DNA; Cell biology; Biology; Biochemistry; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006443251,0.001200641,0.0003443377,0.001088751,0.0003165742,0.0005469472,0.0004167267,0.0008669796,0.001431993],"category_scores_gemma":[0.0002360134,0.0004117466,0.0006865986,0.00029708,0.0004455591,0.0003365897,0.0002454792,0.001210774,0.0007347525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005705109,"about_ca_system_score_gemma":0.0002407682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118346,"about_ca_topic_score_gemma":0.00143546,"domain_scores_codex":[0.9994529,0.0001057482,0.00007532733,0.0001319117,0.0001449588,0.00008919989],"domain_scores_gemma":[0.9996087,0.00008120244,0.0001311167,0.00005283707,0.00004242712,0.00008377433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004534544,0.00006729257,0.0001103027,0.00001413146,0.000006846589,0.00005036651,0.00001231613,0.00006334232,0.9991315,0.0001060064,0.00003294059,0.0003596562],"study_design_scores_gemma":[0.00004174568,0.0006721815,0.002279746,0.000009372086,0.00004493679,0.0005594647,0.00002448477,0.001375081,0.9926374,0.00006601583,0.002281252,0.000008301878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792415,0.001781871,0.014564,0.0002140266,0.00007199995,0.0001828731,0.002260634,0.0002254007,0.001457612],"genre_scores_gemma":[0.9711413,0.001883229,0.01400886,0.0001663996,0.0000335221,0.0003215639,0.004690242,0.0002140044,0.007540744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431993,"threshold_uncertainty_score":0.004790545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03112513891638903,"score_gpt":0.2345275388911877,"score_spread":0.2034023999747987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}