{"id":"W2555266496","doi":"10.1182/blood.v112.11.942.942","title":"Synergistic Cytarabine:Daunorubicin Ratios Delivered by CPX-351 to Human Leukemia Xenografts Is Associated with Liposome-Mediated Bone Marrow Drug Accumulation, Intracellular Delivery of Encapsulated Agents to Leukemia Cells, and Increased Efficacy.","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Daunorubicin; Cytarabine; Leukemia; Bone marrow; Pharmacology; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606115,0.0004680581,0.0002835612,0.000223123,0.0001059587,0.0002891879,0.0001457194,0.0002089438,0.0008289483],"category_scores_gemma":[0.00009223914,0.0001417236,0.0001389701,0.0001578095,0.0001894949,0.000217265,0.000180615,0.0005283343,0.000203648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003179468,"about_ca_system_score_gemma":0.0002314138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000600117,"about_ca_topic_score_gemma":0.0008077361,"domain_scores_codex":[0.9998534,0.00002613998,0.00001211799,0.00003369496,0.00004122511,0.00003335847],"domain_scores_gemma":[0.9999326,0.00001299224,0.00002173851,0.000006659306,0.000006482699,0.00001953812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000755323,0.00003400017,0.00004866316,0.00001274377,0.00000273159,0.0000102732,0.00001049348,0.00008383338,0.9990177,0.00004577924,0.00001513713,0.0006430313],"study_design_scores_gemma":[0.0000110229,0.0004160893,0.0005456617,0.000001307403,0.000006824456,0.00003599298,0.000004925457,0.0006098045,0.9979544,0.00000769318,0.0004047006,0.000001546517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963659,0.000771982,0.001897128,0.00003196552,0.000009165511,0.00004666582,0.0001738412,0.00008509601,0.000618189],"genre_scores_gemma":[0.9973472,0.0003081329,0.001519026,0.000009743945,0.000003259539,0.00002803933,0.0001897427,0.00001628556,0.0005786179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008289483,"threshold_uncertainty_score":0.002773106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537834771082366,"score_gpt":0.2469519566246376,"score_spread":0.231573608913814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}