{"id":"W2555297165","doi":"10.1182/blood-2016-09-739003","title":"CCL2 is a KIT D816V–dependent modulator of the bone marrow microenvironment in systemic mastocytosis","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Austrian Science Fund","keywords":"Systemic mastocytosis; Bone marrow; In vivo; Cytokine; CCL2; Immunology; Medicine; Cancer research; Chemokine; Biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733997,0.0002340452,0.0001739802,0.0001433948,0.0001000842,0.0001964925,0.00008106406,0.0001668191,0.0007674127],"category_scores_gemma":[0.0001136275,0.0000707831,0.0001506708,0.0000844942,0.0001531033,0.0001291345,0.0001554297,0.0002297528,0.0001354621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001424221,"about_ca_system_score_gemma":0.00007698737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001703264,"about_ca_topic_score_gemma":0.0002518696,"domain_scores_codex":[0.9999076,0.0000328815,0.000008103596,0.00001142605,0.00001378753,0.000026132],"domain_scores_gemma":[0.9999466,0.00000916617,0.00001871581,0.000005634225,0.000006345117,0.00001360732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003884578,0.00003497409,0.00342422,0.00006126255,0.000007134009,0.0005036564,0.00002135555,0.00008846027,0.9933724,0.00007726967,0.00008271442,0.001938112],"study_design_scores_gemma":[0.0003162875,0.002571368,0.2246401,0.000048239,0.00009949691,0.005952819,0.0002640756,0.004132846,0.7563208,0.0002838097,0.005349884,0.00002014728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977027,0.001305443,0.0004563378,0.00005185582,0.000007140189,0.00001150206,0.00007406472,0.00001305718,0.0003778632],"genre_scores_gemma":[0.9992,0.0002627159,0.0002147247,0.00001858636,0.000007106755,0.000007307657,0.00008382486,0.000001753625,0.0002039626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007674127,"threshold_uncertainty_score":0.002567232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005478793058310664,"score_gpt":0.170546036336247,"score_spread":0.1650672432779363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}